3304 Results
Role of polarized exocyosis in infection of host cells by pathogenic E. coli
Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are important causes of diarrhoeal disease and hemolytic uremic syndrome in New Zealand and worldwide.Funding proposalsA single-cell transcriptomic approach to gastric cancer heterogeneity
Cancer cells within single tumours are not all the same. Consequently, drug therapies often fail to kill the entire cancer, leading to rapid relapse.Funding proposalsCaffeine to improve neurodevelopmental outcomes in infants born late preterm
Over 3,000 babies in New Zealand are born late preterm (4-6 weeks early) every year. Late preterm babies are at greater risk of disability when they get older than babies born at term.Funding proposalsA vaccine for Staphylococcus aureus
Staphylococcus aureus causes hospital and community acquired disease world-wide and the steady rise of antibiotic resistant strains of S. aureus is of global concern.Funding proposalsTargeting metabolic dysregulation to eradicate drug resistant M. tuberculosis
Antimicrobial resistance is a global health crisis. Drug-resistant strains of Mycobacterium tuberculosis, the causative agent of tuberculosis, are extremely difficult to treat, with long treatment regimens (9-20 months) and low cure rates (2-50%).Funding proposalsThe evaluation of treatment outcomes for methamphetamine dependence in Aotearoa
Methamphetamine (MA) is the second most commonly used illicit drug in Aotearoa New Zealand (NZ).Funding proposalsWNT signalling - a matter of degradation
In healthy animals, cellular processes precisely determine the number and type of cells. One pathway, referred to as WNT signalling, is required for embryonic development and maintaining adult stem cells.Funding proposalsDevelopment of safe, non-addictive pain medications
There is an urgent need for the development of effective pain medication that is also safe. Current pain medications targeting the mu-opioid receptor such as morphine, fentanyl and tramadol are addictive, and are ineffective when used long term.Funding proposalsExploring a twin-track approach to violence elimination for disabled women
Disabled people represent 24% of the New Zealand population, and are twice as likely to experience interpersonal violence than people without lived experience of disability. Disabled women are overrepresented within these statistics.Funding proposalsUnderstanding the impact of rurality on health outcomes and healthcare delivery
Aotearoa/New Zealand has undertaken much less research into the health status of its rural communities than have comparable countries. A barrier to this has been the absence of an agreed definition of 'rural'.Funding proposalsOvercoming antibody-drug conjugate resistance in HER2-positive breast cancer
Antibody-drug conjugates (ADCs), where potent cytotoxins are linked to antibodies for selective delivery to tumours, are approved for the treatment of HER2-positive breast cancer. However, their use is limited by drug resistance.Funding proposalsCritical evaluation of a tumour-targeted cancer therapy for clinical development
Many cancers that disproportionately affect Māori are caused by amplification, mutation or gene fusions in the Fibroblast Growth Factor Receptor (FGFR) family.Funding proposalsThe nGVS study for bilateral vestibular disorders
The inner ear, or vestibular system, is important for the maintenance of balance. Containing specialised receptors, it detects head movement in three-dimensions.Funding proposalsClimate change, heat exposure and child health
Exposure to hot temperatures, even in cooler climates, can lead to significant adverse health outcomes. An estimated 37% of recent heat-related deaths globally have been attributed to human-induced climate change.Funding proposalsA dual-safety system to promote CAR T cell activation and migration
Chimeric antigen receptor (CAR) T cell therapy involves treatment of cancer with genetically-engineered immune cells. However, successful CAR T cell therapy of solid cancers is limited by migration and activation of CAR T cells at the tumour site.Funding proposalsARISE FLUIDS Aotearoa Randomised Controlled Trial
Severe infections are a common cause of hospitalisation and outcomes for Māori are worse. These infections are treated with large volume fluids through a vein (IV fluid) and medicine to increase blood pressure (vasopressors) if fluids fail.Funding proposalsSpatial profiling of tumour tissue to improve lung cancer immunotherapy
Lung cancer has killed more New Zealanders than any other cancer, and is the most common cause of cancer death in Māori.Funding proposalsHCQ4ARF: A randomised trial of Hydroxychloroquine for acute rheumatic fever
Acute rheumatic fever (ARF) is an immune-mediated inflammatory condition triggered by the bacterium group A streptococcus, affecting the joints and heart valves.Funding proposalsHypoxia-selective delivery of DNA-PK inhibitors to tumours
Radiotherapy, in combination with chemotherapy, is used to treat advanced head and neck squamous cell carcinoma (HNSCC), but tumour control within the radiation field is limited by normal tissue toxicity and tumour hypoxia.Funding proposalsRCT budesonide-formoterol reliever therapy in moderate/severe childhood asthma
Childhood asthma is a major public health problem in New Zealand. The evidence base for the treatment of childhood asthma is considerably less than for adult asthma.Funding proposalsHormone-induced adaptations in respiratory function during pregnancy
This proposal aims to reveal the neuronal mechanism controlling maternal respiration during pregnancy. For a healthy pregnancy and to provide sufficient oxygen for offspring development, hormones drive adaptive changes in maternal breathing patterns.Funding proposalsNew targets for infectious disease - tackling antimicrobial resistance
Antimicrobial resistance (AMR) is a significant global health challenge and an imminent threat to New Zealand. The increasing number of extremely drug-resistant pathogenic bacteria has rendered some antimicrobial treatments ineffective.Funding proposalsManaaki Te Iti Kahurangi: Improving outcomes for whānau
Wāhine, pēpi and whānau experience persistent health inequities that impact wellbeing throughout pregnancy, birth and childhood. Without profound system change, there will continue to be unacceptable, avoidable harm and death for Māori.Funding proposalsReducing the burden of osteoarthritis in Aotearoa New Zealand
Osteoarthritis is among the most common long-term conditions in New Zealand. The burden of pain, disability and economic costs is rising – especially for Māori. Access to treatments is poor.Funding proposalsPathogenesis, detection and treatment of perinatal brain injury
Perinatal brain injury is the single greatest cause of disability over the whole of life. The team played a key role in developing brain cooling, now the first established therapy for injury after low oxygen levels at term.Funding proposalsStrategies to improve gout management in Aotearoa
Gout is particularly prevalent in Aotearoa/New Zealand, with 13.8% of Māori men, 22.5% of Pacific men, and 6.9% of New Zealand European men affected.Funding proposalsUpdate 7 July 2022
NewsAustralia New Zealand Society of Palliative Medicine Conference 2022
The conference theme 'Better care for all: Inclusivity, equity and collaboration' is an important theme for our time. It conveys the need to improve the care we all depend on through a more inclusive approach to palliative care that is reliably…EventKai wai ū i te pō: Māori aspirations around breastfeeding in Te Tai Tokerau
This project is driven by the aspirations from Te Tai Tokerau around wai ū/breastfeeding.Funding proposalsSupporting the Integrated Practice Model: Digital Tool Implementation Research
Mental health services are not equitably meeting the needs of the New Zealand population.Funding proposalsTranslating Pacific Health Research to improve Pacific Housing
How do we apply Pacific Health models (PHm) in a meaningful way to improve Pacific housing solutions?Funding proposalsDeveloping an automated image-based dietary assessment tool
Our project is focused on empowering Kiwis' health by understanding their diet.Funding proposals