3389 Results
He rapunga hauora mō te mate wareware: A prevalence study
The health and wellbeing of our kaumātua/pākeke is under threat. Māori have a higher prevalence of risk factors for mate wareware and therefore are more likely to suffer from this disease.Funding proposalsThe CALCRL receptor: A new genetic determinant of diabetic kidney disease in New Zealand
Diabetic kidney disease is a major health issue in New Zealand. Māori and Pacific people are particularly affected, with genetics being a likely component of this inequity.Funding proposalsA randomised controlled trial of a low dose serotonergic agonist for depression
Mood disorders are a leading cause of health loss in New Zealand, however, current treatments do not work or are not well tolerated by a large number of people who suffer from these disorders.Funding proposalsTIAKI – Community wellbeing for whānau with lived experience of incarceration
As experienced by Indigenous peoples globally, Māori experience unjust mass incarceration, impacting on the health and wellbeing of not only those who are incarcerated but their whānau and communities.Funding proposalsAdvancing palliative care among Pacific children
Palliative care in Aotearoa New Zealand (NZ) aims to support quality of life until death, while also supporting family, whānau, and caregivers throughout this process, often into bereavement.Funding proposalsEarly brain development and later outcomes in moderate-late preterm babies
Babies born preterm are at increased risk of impaired lifelong health and wellbeing.Funding proposalsHe Toa Taumata Rau - The Many Resting Places of Courage
Transition from military to civilian life can be a critical period for Māori veterans and a challenging time for their whānau (Perlick et al., 2017).Funding proposalsNovel biomarker validation to guide treatment in inflammatory bowel disease
Inflammatory bowel disease (Crohn's disease and ulcerative colitis) are common in New Zealand. There is no cure and young people live with severe gut symptoms such as pain, diarrhoea, weight loss and bleeding.Funding proposalsGenomic epidemiology of human respiratory viruses in Aotearoa
New Zealand’s interventions to control COVID-19 have eliminated respiratory viruses that ordinarily circulate annually.Funding proposalsWhānau-centric coronial processes to improve suicide prevention strategies
The high rates of rangatahi (Māori youth) suicide provide one of the starkest social and health disparities that exist between Māori and non-Māori. This project builds on a research activation grant that investigated coronial processes and how these can bFunding proposalsHow can we improve eye, hearing and feet health for kaumātua/older adults?
Older adults commonly experience sensory impairment due to their eye, hearing or foot health, particularly if they also live with diabetes.Funding proposalsMā te mōhio ka mārama (M2M). Impact of COVID-19 on Māori:non-Māori inequities
This study will document the impact of COVID-19 pandemic management on Māori:non-Māori inequities in health at both a nation-wide and regional level.Funding proposalsNeuron-glia regulation of plasticity in health and neuroinflammatory diseases
Plasticity at synaptic junctions between nerve cells is fundamental to learning and memory. Such plasticity is generated not only by nerve cell activity, but it is also highly regulated by activity in nearby non-neural cells.Funding proposalsWhiria te tāngata: Out-of-home mobility of Māori and non-Māori over 65 (NZPATHS)
Stopping driving can result in depression, declining health, and social isolation. Transitions to driving cessation and alternative transport can be difficult for older drivers and whānau/families.Funding proposalsDevelopment of rifampicin as inhaled therapy for tuberculosis
Tuberculosis causes over ten million infections and over one million deaths each year. Treatment requires a long course of multiple antibiotics and is suboptimal: poor adherence, side effects, antibiotic resistance and treatment failure are common.Funding proposalsImproving genetic health through RNA diagnostics
The development of next-generation sequencing technologies over the past decade has revolutionised genetic testing of high-risk cancer patients in a diagnostic setting.Funding proposalsIs Exendin-4 neuroprotective after perinatal hypoxia-ischaemia?
Low oxygen and impaired blood supply to the brain (hypoxia-ischaemia, (HI)) around birth is associated with death, brain damage and disability in about 2/1000 live term births in New Zealand.Funding proposalsBringing precision to the diagnosis of complex neurodevelopmental disorders
Neurodevelopmental disorders affect 3-5% of children but frequently management options are limited by diagnostic imprecision.Funding proposalsWhat does dementia mean for Pacific communities in New Zealand?
There are no Pacific terms for dementia. The aging Pacific population will see a 2.5-fold increase in those aged 65+ by 2026.Funding proposalsHormones and mood: Imaging the impact of obesity on maternal neural circuitry
Healthy mother-infant interactions are critically important for a child’s development.Funding proposalsRegulating retail vaping to support smoking cessation
E-cigarette use in Aotearoa/New Zealand has increased rapidly in recent years, particularly among youth and Māori.Funding proposalsActivity of orexigenic AgRP neurons during pregnancy and lactation
Expecting mothers need to increase food intake to meet the energy demands of the growing fetus, and to store energy as fat in preparation for lactation.Funding proposalsImmune cells, bacteria and epithelium in Crohn's disease patients
Approximately 15 000 people in New Zealand are diagnosed with Crohn’s disease (CD), a chronic inflammatory disease that mainly affects the gut.Funding proposalsIs acute rheumatic fever primarily caused by scabies? A case-control study.
Increasing evidence suggests that acute rheumatic fever (ARF) is primarily caused by scabies infestation.Funding proposalsEvaluating a bedside high-sensitivity troponin within a rural chest pain pathway
Currently patients that present to most rural health facilities do not have access to the same highly precise and sensitive blood tests used to investigate chest pain suspected to be from a cardiac cause.Funding proposalsTargeted immune stimulants to hypersensitise lung cancer to checkpoint blockade
In Aotearoa New Zealand, 9 out of 10 lung cancer patients die within five years despite treatment, with the mortality rate for Māori being 3.5 times greater than for non-Māori.Funding proposalsRole of polarized exocyosis in infection of host cells by pathogenic E. coli
Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are important causes of diarrhoeal disease and hemolytic uremic syndrome in New Zealand and worldwide.Funding proposalsA single-cell transcriptomic approach to gastric cancer heterogeneity
Cancer cells within single tumours are not all the same. Consequently, drug therapies often fail to kill the entire cancer, leading to rapid relapse.Funding proposalsCaffeine to improve neurodevelopmental outcomes in infants born late preterm
Over 3,000 babies in New Zealand are born late preterm (4-6 weeks early) every year. Late preterm babies are at greater risk of disability when they get older than babies born at term.Funding proposalsA vaccine for Staphylococcus aureus
Staphylococcus aureus causes hospital and community acquired disease world-wide and the steady rise of antibiotic resistant strains of S. aureus is of global concern.Funding proposalsTargeting metabolic dysregulation to eradicate drug resistant M. tuberculosis
Antimicrobial resistance is a global health crisis. Drug-resistant strains of Mycobacterium tuberculosis, the causative agent of tuberculosis, are extremely difficult to treat, with long treatment regimens (9-20 months) and low cure rates (2-50%).Funding proposalsThe evaluation of treatment outcomes for methamphetamine dependence in Aotearoa
Methamphetamine (MA) is the second most commonly used illicit drug in Aotearoa New Zealand (NZ).Funding proposals