3304 Results
Lung protection during critical illness
At the heart of managing the critical illness patient is preservation of lung function and thus ensuring appropriate exchange of the gases needed for living.Funding proposalsHBsAg mutations and pathophysiology of chronic hepatitis B.
A chronic hepatitis B virus (HBV) infection causes life-threatening complications including cirrhosis, cancer and severe hepatitis. These complications are all associated with mutations in viral proteins.Funding proposalsLooking Skin Deep
Deep to the skin surface is a network of blood capillaries that transport blood and nutrients to the skin and take waste away.Funding proposalsSynthesis of a million stories with natural language processing
Accounts of addiction are highly prevalent in online forums and community message boards.Funding proposalsResurrection of an anti-inflammatory therapy through protein engineering
Inflammatory diseases represent a huge global burden, but the medicines we have to treat them are limited.Funding proposalsContinuous dynamic monitoring of lung function at the bedside
For decades, monitoring of lung function during mechanical ventilation in critical care patients has been limited to measurements taken externally.Funding proposalsSewers for Superbug Surveillance
Antibiotic-resistant superbugs pose a serious threat to human health. Within a decade, many routine medical procedures and treatments could become life-threateningly risky.Funding proposalsA collaborative AR work and presentation tool to examine tumour evolution
This project aims to produce a prototype augmented reality (AR) application and presentation space to enhance understanding of how cancer evolves in a single patient.Funding proposalsThe placental clock: Investigating mechanisms of stillbirth
We intend to perform a large-scale biobanking project in which tissue for histology and RNA analysis is collected from women at risk for stillbirth.Funding proposalsFighting Splicing with Splicing: New Strategies for CAR T cell Immunotherapy
Cancer treatment has been revolutionised by the engineering of patient T cells ex vivo with artificial T cell receptors (CAR) that hardwire T cells to attack cancer cells.Funding proposalsIs our destiny in our genes? Using Mendelian genetics to refine cancer risk
Genetic and sequencing studies have identified many genes which increase risk or predispose to getting cancer. In contrast, there is little known about which genes could harbour alterations which could act protectively and reduce this risk.Funding proposalsEarly mitochondrial dysfunction assay for neurodegenerative diseases
We will develop a novel early detection assay for neurodegenerative diseases. The assay will have the potential to measure loss of mitochondrial gene expression decades before symptoms of dementure appear, at a time when sense of smell begins to decline.Funding proposalsCodesign of Augmented Reality Stroke Rehabilitation from Te Whare Tapa Whā
Our transformative intervention melds socio-digital properties with indigenous insights into an augmented reality (AR) system to create healthtech, or digital health, that motivates and guides older adults to exercise for stroke rehabilitation.Funding proposalsDesigning synergistic combinations to prevent antibiotic resistance
Synergistic antibiotics interact positively with each other to give more than the sum of their individual benefits.Funding proposalsHow do antimicrobial combinations suppress development of resistance?
Antibiotics are arguably the most important and successful medicines of all time. However, bacteria have evolved resistance towards many individual antibiotics.Funding proposalsPartnering with whānau to address inequities to pain management
Chronic or persistent non-cancer pain affects one in five New Zealanders. Persistent pain disproportionately affects Māori and their whānau.Funding proposalsDeveloping serotonergic 2A receptor agonists as treatments for mood disorders
Mood disorders are a leading cause of health loss in New Zealand, however, current treatments do not work or are not well tolerated by large number of people who suffer from these disorders.Funding proposalsUnravelling the mysteries of yersiniosis
Yersiniosis is a debilitating enteric infection predominately caused by the bacteria Yersinia enterocolitia (YE). There is currently an unexplained and increasing epidemic of yersiniosis in New Zealand (NZ), with 1,186 notified cases in 2019.Funding proposals'Mā wai e tō taku kauwae ki uta' - who will take my place?
Initial findings of Ngati Pikiao Iwi Trust’s research into the positive aging of Ngati Pikiao (NP) peoples indicates that kōeke (elders) fulfilling paepae (marae cultural) duties are tired.Funding proposalsTe Puna Taiao - Improving health outcomes for tamariki
This Māori community-based research project aims to contribute to generating an evidence base around improving health outcomes for tamariki Māori through enrichment and best use of primary school natural envionments.Funding proposalsDeveloping a Decision Support System at ED triage for predicting health outcomes
Emergency department overcrowding is a major global healthcare issue. The consequences are well-established, usually affecting patients (poor outcomes), staff (stressed) and healthcare system (long length of stay).Funding proposalsGetting ready for the first clinical trial for Māori with dementia
The Māori population is ageing at a faster rate than their Pākehā counterparts. The number of Māori diagnosed with dementia will increase in the coming decades.Funding proposalsTihei Rangatahi Programme: Improving hauora-oranga services for rangatahi Māori
The Tihei Rangatahi Programme (TRP) is part of Kōkiri health and social services in the Wainuiomata and Lower Hutt region. Hauora-oranga services was identified as a gap in the services for rangatahi Māori.Funding proposalsSpatial oculomics with imaging mass spectrometry for drug delivery
Dr Gus Grey is a Sir Charles Hercus Senior Research Fellow, and recognised expert in the analysis of ocular tissues with imaging mass spectrometry.Funding proposalsInvesting in Māori health research
Māori health research is that which values Māori worldviews and builds Māori research capacity and leadership.General informationDo locality network partnerships improve health system performance and outcomes?
Collaborative partnership working across local health systems is fundamental to New Zealand health service delivery and improvement.Funding proposalsA clinical:research alliance for diagnosing genetic disorders in New Zealand
Human genetics has been transformed by the advent of high-throughput sequencing, and many countries have instigated national initiatives to deliver clinical-based exome sequencing as a first-tier test, often with a strong preclinical arm to drive further vFunding proposalsScoping an online ‘research ready’ lifestyle programme for type-2 diabetes
Type-2 diabetes (T2D) is an inequitable health burden in New Zealand.Funding proposalsImproving blood safety and donor selection
Our medical care relies on a safe, sufficient blood supply. This project, in partnership with the NZ Blood Service (NZBS), seeks to minimise risk to the blood supply while maximising blood donations.Funding proposalsReflecting informed choice in population screening: Progressing equity
Population screening programmes begin with an invitation to participate.Funding proposalsCryopreserved vs. Liquid Platelets for Surgical Bleeding (CLIP-II NZ)
Bleeding after major surgery, traumatic injury or associated with medical conditions can be life threatening.Funding proposalsAssessing the oral health sector’s organisational commitment to equity
Equity is a key priority of NZ’s health system, and for Māori, a constitutional right. Yet, severe, unacceptable and avoidable disparities in oral health persist.Funding proposals