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Parkinson's in New Zealand: Genes and environmental exposures

Year:
2021
Duration:
36 months
Approved budget:
$1,199,252.93
Researchers:
Dr Toni Pitcher
,
Dr Daniel Myall
,
Associate Professor Andrea 't Mannetje
,
Professor Martin Kennedy
,
Dr Alastair Noyce
,
Dr Mark Simpson
,
Professor Tim Anderson
Health issue:
Neurological (CNS)
Proposal type:
Project
Lay summary
Parkinson’s disease is a progressive neurodegenerative disorder affecting approximately 12,000 New Zealanders. The motor function impairments and accompanying behavioural and psychological symptoms of the disorder reduce the quality of life of both patients and their support networks. Genes and environmental exposures both contribute to the occurrence of the disorder. In this study of 500 Parkinson's cases and 500 controls, we will identify occupational and other environmental exposures associated with Parkinson's in New Zealand. We will also identify the Parkinson's-associated genetic risk factors present in the New Zealand population. This data will be used to identify areas where education and policy changes may be applied to help reduce exposure to factors shown to increase risk. We will test predictions from a new model of Parkinson's and contribute to important international efforts to further our understanding of the role of genes in the disorder.