3309 Results
Preclinical development of non-addictive pain medications
Chronic pain affects 1 in 6 New Zealanders, robbing them of their quality of life. Chronic pain is poorly treated with current mu-opioid medications such as morphine, which become ineffective with long-term use and have high abuse potential.Funding proposalsOne cell, two phenotypes: capturing pluripotency for tisse repair
We propose a method of in vivo tissue repair based on the modulation of cell microenvironment via the application of specific growth factor/chemical combinations to harness adult cell differentiation.Funding proposalsNutrition 2.0: Toward a food systems approach for public health nutrition
Unhealthy diets are a key contributor to mortality in New Zealand (NZ) and we are in high need for workable solutions to improve population diets. However, food is not just about health. In fact, the NZ food system is the major contributor to the economy.Funding proposalsCan we rehabilitate a reflex? A treatment protocol for the cough reflex
Neurological disease or injury can damage the cough reflex, which is critical for protecting the airway from foreign matter during swallowing.Funding proposalsIntelligent digital environment for wellbeing and healthcare
This research investigates an innovative and novel approach to the delivery of health care support to older people.Funding proposalsA novel nanosensor array for heart failure diagnosis
We propose a series of experiments to prove the utility of a novel sensor in the diagnosis of heart failure. This sensor measures molecules in the air, and can be used to measure markers of disease in breath or other body fluids such as urine.Funding proposalsDesigning diagnostic and rehabilitation landscapes for the disabled
The research will develop a New Zealand appropriate set of design parameters for a series of walking paths that both measure and track the physical progress and/or regress of the aged as well as those who are or have been physically or mentally disabled.Funding proposalsTargeting HP1 regulated pathways to suppress breast cell invasion
Metastasis is the primary cause of death in breast cancer patients as it refractory to current therapies. The first step in metastatic disease occurs when a cell invades surrounding tissue.Funding proposalsUsing CRISPR-Cas9 to predict sensitivity to trastuzumab emtansine
Over 3000 diagnoses and 600 deaths are attributable to breast cancer in New Zealand each year. One-quarter of breast cancers is driven by increased amounts of a gene called HER2, which can be targeted with the drug trastuzumab (Herceptin).Funding proposalsCollaborative fever etiology research in South East Asia
1. Collaborate to conduct Myanmar's first comprehensive severe febrile illness etiology study to improve patient management and target disease prevention efforts. 2.Funding proposalsKimihia te hauora hinengaro: pathways for Maori mental health
While some research to date has provided much needed insight into the mental health needs and subsequent service use of Maori more broadly, little is known about the prevalence of mental health disorders or service uptake in West Auckland specifically.Funding proposalsTe ohu mo Papatuanuku: contaminated site toolkit for community use
The Te Ohu Mo Papatuanuku collaboration aims to assist tangata whenua within the Ngati Awa rohe to address contamination issues on their lands.Funding proposalsHe puna reo he puna oranga whanau: Impact of urban puna reo on health & wellbeing
This research project (the project) explores the impacts of an urban based Māori Puna Reo (early childcare within a kaupapa Māori context) on the health and wellbeing of tamariki and their whānau with a specific focus on taha wairua, taha hinengaro, taha tFunding proposalsImproving child and whanau health outcomes - intervention in early life settings
The purpose of the study is to contribute to generating an evidence base around what constitutes effective early life kaupapa Māori programming for tamariki and whānau that will lead to improved health outcomes in later life (across the lifespan) for tamarFunding proposalsMahi Ngātahi - Culturally responsive ways of working together
Māori as Aotearoa New Zealand’s indigenous people and partners to the Treaty of Waitangi are entitled to experience the same level of health and wellbeing as non-Māori. However, research and growing health disparities suggest this is not the case.Funding proposalsImpact of sugar-sweetened beverage taxation in the Pacific
Given the scale of the global obesity epidemic it is critical to understand if interventions to control obesity are effective.Funding proposalsDeciphering gender and ethnic disparity in obesity and cardiometabolic disease
New Zealand has the third highest rates of obesity in the world. Despite decades of effort to reduce these rates, they continue to rise, particularly in young women and especially amongst Māori and Pacific.Funding proposalsPrevention and treatment of fever in the ICU
Many critically ill patients are unable to respond to the demands that fever places on the body. One potential way to protect patients from the adverse clinical effects of fever is to systematically prevent and treat fever.Funding proposalsImpact of built environment interventions on children's physical activity
I have a cohesive research programme directed at understanding socio-environmental associates and predictors of children’s activity and body size.Funding proposalsThe effects of comorbidity on breast cancer care and outcomes
Dr Melissa Edwards is a general surgical trainee undertaking a PhD in Surgery on the impacts of comorbidity on breast cancer care and outcomes in New Zealand women. The co-existence of breast cancer and chronic concomitant disease/s is not uncommon.Funding proposalsImproving outcomes for support workers in aged care
I am a young researcher passionate about aged care. My intention is to put my stake in the ground and become an expert in this important area.Funding proposalsThe rectosigmoid brake and its utility as a neuromodulation target
Colon motility disorders and faecal incontinence are common and have a significant financial burden and impact on the quality of life. However we have limited knowledge of human colon motor patterns.Funding proposalsGeographic and ethnic inequities in stroke outcomes
Stroke is the third most common cause of death and the most significant cause of adult disability in New Zealand. We know of several key interventions that reduce disability after stroke.Funding proposalsDementia and Parkinson's disease: tau pathology and cerebrovascular health
Many people with Parkinson’s develop cognitive problems and, eventually, dementia. We need to identify suitable objective tools that measure the underlying brain changes associate with cognitive decline.Funding proposalsNovel osteoprogenitor cell populations involved in bone healing
Bone tissue is constantly replaced throughout life in a process known as remodelling. Bones also have a remarkable capacity to heal following fracture.Funding proposalsTargetting a zinc link in the treatment of Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) are characterised by impaired communication and social behaviours. ASD-associated mutations occur in the Shank family of synaptic proteins, and we have shown that these mutations weaken synapse function in the brain.Funding proposalsNovel metabolic processes to target persistent tuberculosis
Our poor understanding of the phenomenon of persistence is the greatest roadblock to improved treatment of tuberculosis (TB), leading to latent disease and severely restricting the utility of current drugs.Funding proposalsD3: Data, Decision-making & Development: using data to improve health outcomes
Routinely collected health data has been successfully used to describe “the problem” of persisting inequalities and to inform potential ‘solutions’. However, increasing attention is now being paid to data utility and relevance.Funding proposalsThe impact of racism on the future health of adults: a prospective cohort study
Racism – at an individual or structural level – is recognised as an important determinant of health.Funding proposalsTargeting IGF-1 signalling for repair of preterm brain dysmaturation
Very premature babies continue to have extremely high rates of long-term neurodevelopmental deficits.Funding proposalsRole of host exocytosis in infection of human cells by Listeria monocytogenes
Listeria monocytogenes is a potentially deadly cause of food-borne illnesses including meningitis and abortion.Funding proposalsKorero mai: taitamariki Maori development of healthy relationships
Young people’s intimate partner violence (IPV) and specifically taitamariki Māori IPV is an important issue for Aotearoa New Zealand. Māori women have higher rates (58%) of IPV than European women (34%) (Fanslow et al, 2010).Funding proposals