Gastric (stomach) cancer is the 2nd greatest cause of cancer death worldwide. In New Zealand, it is remarkable for its incidence in Maori and Pacific people being three fold greater than in non-Maori. It is clear that a significant proportion of the gastric cancer burden in New Zealand could be avoided by an improved understanding of environmental and genetic risk factors, better diagnostic methods, more accurately targeted treatments and improvements in health delivery mechanisms. These gains will have particularly benefit for our highest risk populations, thereby reducing health inequalities. In this research, our goal is to reduce the burden of gastric cancer in vulnerable New Zealand populations through a series of linked, multidisciplinary projects.