Lay summary
Metabolic regulation is key for health and longevity and defects in these systems cause obesity, diabetes and some cancers, which are high-impact diseases worldwide and especially in NZ. The Igf2 gene was understood to be translated into a single hormone, IGF-II. The discovery of preptin and vesiculin in insulin containing islet secretory vesicles has challenged this dogma. Both peptides have been shown to be active, both are secreted along with insulin and both are likely to have important roles in glucose regulation and pancreatic function. Although it has been over a decade since they were discovered there is little known about them. Understanding all the elements at play in metabolic regulaton is crucial to develop new treatments against such diseases. This research will provide a platform upon which I can develop as a reputable independent researcher as well as building future capability in an area with importance for New Zealand