3309 Results
Development of an optimal hypoxia-selective cytotoxin for clinical use
Mismatch between oxygen supply and demand results in tumour hypoxia (low oxygen), a major impediment to successful treatment outcomes in cancer management.Funding proposalsThe epidemiology of respiratory syncytial virus (RSV) in New Zealand children
I was introduced to epidemiology while doing a Masters in Public Health at the University of Otago.Funding proposalsReducing heart failure readmission: the IMPERATIVE-HF study
Heart failure is a common condition and a major cause for hospitalisation in adults. One in four patients hospitalised with HF will be readmitted within 30 days of discharge.Funding proposalsPacific Islands Families Study: impact of hearing loss on Pacific youth
Hearing impairment and deafness are serious disabilities that impose a heavy social and economic burden on individuals, families, communities and countries.Funding proposalsImplantable light stimulator to treat Parkinson’s disease.
Parkinson’s disease (PD) affects 10,000 people in New Zealand. Current drug and deep brain stimulation treatments help reduce symptoms, but they also produce unwanted side effects.Funding proposalsGnRH neuron control of ovulation
Nearly 40% of women suffering from infertility are unable to ovulate normally.Funding proposalsDefining human specific genetic variants in brain developmental disorders
Stem cells within the developing human brain have the potential to repair neurological damage whether it be caused by in-born or acquired factors. A limited understanding of the genetic regulation of these cells limits the exploitation of this capability.Funding proposalsDevelopment of a novel and specific inhibitor of CSF1R for cancer therapy
White cells (macrophages) play an important role in promoting the growth and invasion of cancers by generating protein factors that suppress the body’s immune responses and increasing tumour blood supply.Funding proposalsTargeting crystal-driven macrophage activation to suppress gouty inflammation
Gout is the most common inflammatory arthritis in New Zealand. Of significance, Māori and Pacific people have the highest prevalence of gout worldwide.Funding proposalsTargeting the ERp44-adiponectin interaction for diabesity treatment
Adiponectin is a protein hormone with remarkable remedial activities against most obesity-related disorders, where its otherwise high serum level is drastically reduced.Funding proposalsPae Herenga: An investigation of Māori whānau end of life cultural care customs
This study will investigate the traditional end-of-life Māori care customs that whānau draw on to strengthen their end-of-life caregiving activities and support palliative care service provision.Funding proposalsHarnessing the spark of life: Maximising whānau contributors to rangatahi wellbeing
Utilising high quality Kaupapa Māori qualitative and quantitative approaches, the present research will build on current Māori knowledge pertaining to whānaungatanga, and increase understanding into the mechanisms and pathways through which whānau relationFunding proposalsBacteraemia Antibiotic Length Actually Needed for Clinical Effectiveness-BALANCE
The optimal duration of antibiotic treatment for critically ill patients with bloodstream infections is unknown. There is evidence in less severe infections that shorter durations of antibiotic treatment are as equally effective as longer durations.Funding proposalsDevelopment and application of a risk prediction tool for emergency laparotomy
Emergency laparotomy is a commonly performed surgical procedure with a high mortality and morbidity.Funding proposalsAssessing and comparing national policy to reduce harmful use of alcohol
Using unique data from the International Alcohol Control (IAC) study this research will develop two new International Alcohol Control Policy Indices, one for youth and one for adults, comparable across high and middle income countries.Funding proposalsTūhono Māori: Promoting secure whānau relationships for traumatised mokopuna
Finding healthy solutions for traumatised mokopuna Māori is of critical concern where early interventions must begin with our most vulnerable. This research proposes to develop tūhono (relationship bonds) as a contemporary Māori attachment theory.Funding proposalsDoes sleep differ according to ethnicity in children?
An analysis of accelerometer data from over 1000 children gathered over 7 night's sleep, in order to determine whether there is any variation in duration, timing, and/or variability differ between ethnicities of children in New Zealand.Funding proposalsUsing the InterRAI to improve identification and management of frailty
Older people with frailty are more vulnerable to sudden declines in health in response to seemingly small trigger events such as drug side effects or overmedication.Funding proposalsEvolution of an epidemic: emergence and adaptation of group B meningococci in NZ
Infectious disease outbreaks and epidemics are a significant burden on health systems. Understand what constitutes epidemic potential, how epidemics emerge and their subsequent evolution can inform surveillance and reduce future epidemics.Funding proposalsIntegrated services to improve the health of Pacific peoples
In this research, we are interested in better understanding the health and social services delivery experiences of Pacific families with complex needs.Funding proposalsUnmasking genes for antibiotic resistance in a superbug
The rapid rise of superbugs - bacteria that are resistant to all available antibiotics - is an increasing threat to health with the potential to overwhelm the healthcare system.Funding proposalsA qualitative look at Tikanga best practice guidelines in New Zealand DHBs
Cultural competence has been suggested to be an integral part of clinical care, and can improve patient outcomes when integrated successfully.Funding proposalsReducing inequity through timely detection of critical congenital heart disease
Congenital heart defects (CHD) are the most common congenital malformations. If diagnosed late, babies can become extremely unwell with long-term implications for health and neurodevelopment.Funding proposalsAn epigenome-wide study for coronary artery disease
Coronary artery disease (CAD) is the leading cause of death in our community. Unfortunately, current risk prediction tools lack both sensitivity and specificity and there is a clear need to develop improved methods of identifying those at risk.Funding proposalsIntegration of inflammatory signalling by TNF receptor associated factors
Initiation and resolution of inflammation is essential for cellular homeostasis, and aberrations are associated with a range of diseases. Regulation of inflammation relies on signals transmitted from receptors on the surface of cells to the nucleus.Funding proposalsThe BEST-Fluids study: Better Evidence for Selecting Transplant Fluids
End-stage kidney disease (ESKD) is a significant, expensive health problem that affects 4,500 New Zealanders and their families. Kidney transplantation improves survival, quality of life, and is much cheaper than dialysis treatment for ESKD.Funding proposalsReducing delay and increasing access to early diagnosis for colorectal cancer
Early diagnosis is a key factor in improving outcomes for colorectal cancer patients.Funding proposalsKidney organoids: modelling kidney injury and preclinical drug testing
Kidney disease is major health issue in New Zealand with an estimated 1:10 people having some degree of chronic kidney disease.Funding proposalsFollow up of hip and knee arthroplasty patients returned to GP
Hip and knee joint replacements are relatively expensive to provide, but are one of the most cost effective and successful interventions provided by the orthopaedic profession. In Otago there has been an ever increasing demand for surgery.Funding proposalsImproving early access to lung cancer diagnosis for Maori and rural communities
Lung cancer survival in New Zealand is poor especially for Maori. This is because lung cancer is generally diagnosed at a late stage. Early stage cancer can be cured in 75% of patients.Funding proposalsDoes a Whanau Ora approach improve outcomes for hospitalised tamariki?
We like to think that hospital staff will ensure their patients can stay well. Unfortunately staff do not have the right tools, and 1/2 of hospitalised tamariki Maori aged 0-4 are readmitted within months of going home.Funding proposalsAntibiotic prophylaxis and the progression of ARF to RHD
The effectiveness of interventions aiming to control acute rheumatic fever (ARF) and prevent its dangerous sequela rheumatic heart disease (RHD) is limited by a lack of knowledge of the ARF causal pathway.Funding proposals