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A randomised controlled trial of a low dose serotonergic agonist for depression

36 months
Approved budget:
Associate Professor Suresh Muthukumaraswamy
Associate Professor David Menkes
Dr Rachael Sumner
Dr Nicholas Hoeh
Associate Professor Frederick Sundram
Dr Todd Smith
Dr Lisa Reynolds
Dr Rhys Ponton
Dr William Evans
Health issue:
Mental health (and sleep disorders)
Proposal type:
Lay summary
Mood disorders are a leading cause of health loss in New Zealand, however, current treatments do not work or are not well tolerated by a large number of people who suffer from these disorders. Anecdotal reports suggest that low doses of serotonergic 2A receptor agonists are able to positively improve symptoms of depression and anxiety, however, this has yet to be adequately tested in clinical trials. In this research, we will conduct the first randomised control clinical trial using repeated low doses of a serotonergic 2A receptor agonist in patients with major depressive disorder. Our results will indicate whether this approach works and could be followed up by future larger multi-site trials