3304 Results
Preventing upper respiratory tract infections in infancy
In this proposed study we will investigate the effect of a daily oral probiotic (BLIS) on preventing very common infectious problems during early infancy, particularly otitis media, reducing dental caries, upper respiratory tract infections and acute strepFunding proposalsOsteoarthritis: a case of cellular mismanagement?
My goal is to utilise the skills obtained during 5½ years of postdoctoral training in the field of musculoskeletal cell biology to identify the mechanisms underlying the development of osteoarthritis.Funding proposalsPerioperative care in chronic rhinosinusitis
I am a medical doctor specialising in otolaryngology, currently in my 7th postgraduate year. It is my ambition to become an academic surgeon in New Zealand with a focus on diseases of the ear, nose and throat.Funding proposalsTimekeeping in the neural network controlling fertility
Fertility is controlled by a complex neuronal network in the brain that drives the activity of the gonadotropin releasing hormone (GnRH) neurons.Funding proposalsTaking charge after stroke (TACAS)
My career goal is to become a leading clinical researcher and academic neurologist. Completing a PhD in stroke rehabilitation is crucial to achieving this goal.Funding proposalsVitamin C requirement and mechanisms of action in severe infection
Severe sepsis and septic shock cause multi-organ failure and refractory hypotension, and are the leading causes of mortality in critically ill patients.Funding proposalsCan placental stem cells be used to improve fetal outcomes?
Dr James' career is built on understanding how the placenta functions to ensure pregnancy success.Funding proposalsSerotonin agonists to prevent post-operative ileus after abdominal surgery
I am a medical doctor commencing a PhD with the Department of Surgery at the University of Auckland. My aim is to develop a career in academic colorectal surgery.Funding proposalsPredicting brain tumour prognosis from cell immortality pathways.
High-grade brain tumours are largely incurable. They arise in the brain, or start elsewhere and metastasise to the brain. Despite most people having a poor prognosis some individuals live considerably longer.Funding proposalsExploring and improving hospital care quality for New Zealand rural communities
I have been a General Practitioner for 20 years, holding senior health leadership and system redesign roles since 2004. I have an MSc in Public Health. I want to redirect my efforts towards research to effect health system change.Funding proposalsEthnic differences in energy metabolism among New Zealanders
Obesity is predicted to be the leading cause of health loss in New Zealand by 2016. According to recent Ministry of Health data, almost 1 in 3 adult New Zealanders are obese, however rates are closer to 49% for Maori and 68% for Pacific adults.Funding proposalsThermal properties of the liver: improving outcome from ablation of liver cancer
I am currently in my first year as a doctoral candidate with the Univeristy of Auckland.Funding proposalsA model of care for Māori and Pacific People with chronic airways disease
Maori and Pacific People with chronic airways disease fall through the gaps in our healthcare system resulting in increased morbidity and mortality compared with the rest of the New Zealand population.Funding proposalsNo smokers left behind: A trial of adaptive smoking cessation treatment
Around 85% of stop-smoking attempts using ‘gold-standard’ cessation treatment fail. New Zealand’s goal of lowering smoking rates to 5% by 2025 is thus unlikely to be achieved unless more effective treatments quickly become available.Funding proposalsPrescription medicine use in pregnancy
For many medicines, safety information regarding use in pregnant women is lacking but their use during pregnancy has increased considerably in recent decades.Funding proposalsA head-to-head trial of cytisine and varenicline for smoking cessation
Cytisine, a natural product, found in plants such as the Golden Rain and New Zealand Kowhai, partially blocks the effects of nicotine on the brain.Funding proposalsZoledronic acid and fracture prevention in early postmenopausal women
Fractures are a major health problem, occurring in >50% of older women. Low bone density is a strong risk factor for fracture, but 80% of fractures occur in women without low bone density.Funding proposalsIL-1 signalling and developmental programming of offspring metabolic health
Unravelling how early life in the womb adversely affects future disease risk of the child is critical to reversing the obesity and diabetes epidemic.Funding proposalsTe ara auahi kore
The Te Ara Auahi Kore (TAKe) research project will provide much needed high quality evidence for addressing smoking disparities between Māori and non-Māori and achieving a Tupeka Kore (Tobacco Free) Aotearoa 2025.Funding proposalsA Māori approach to the assessment and management of dementia
As kaumatua experience increasing life expectancy, the prevalence of dementia for Maori is also predicted to increase. In 2011, 1,928 Maori were estimated to have had dementia which is expected to increase to 4,493 by 2026.Funding proposalsTargeting the RFRP neuronal system to control stress and anxiety
Hyperactivity of the stress axis is thought to be one of the fundamental underlying drivers of psychiatric conditions such as generalised anxiety and depression.Funding proposalsNovel radiosensitisers for head and neck cancer
Radiotherapy is the primary treatment for advanced head and neck cancer and this treatment is often compromised by cancer cells containing low levels of oxygen (hypoxia).Funding proposalsHigh flow nasal cannulae therapy in COPD and heart failure
Chronic Obstructive Pulmonary Disease (COPD) and heart failure are notable contributors to poor health outcomes in New Zealand.Funding proposalsImplementing a science-based approach for fatigue risk management in nursing
DHBs are required to manage nurses’ fatigue as a workplace hazard and shift work as a cause of fatigue (HSE Amendment Act, 2002).Funding proposalsKeramatrix4VLU: a trial of wool-derived keratin dressings for venous ulcers
Leg ulcers are a common, costly and debilitating condition with few proven treatment options.Funding proposalsGenerating pulses with KNDy neurons
The brain controls the levels of hormones circulating in the blood. The fertility hormones are secreted in a pulsatile manner that is essential for normal reproduction in humans.Funding proposalsSupporting informed e-cigarette use: A mixed methods study
Although electronic cigarettes (ECs) could reduce the harm caused by smoking, they may also present risks. While smokers would benefit if they replaced smoked tobacco with ECs, many continue smoking and remain at risk of serious harm.Funding proposalsPhysiological pacing to improve cardiac output in heart failure
A third of people diagnosed with heart failure die within the first year. The survivors have severely impaired quality of life because even day to day menial activities leave them breathless and incapacitated.Funding proposalsEffect of early childhood ear infections on language, cognition and behaviour
The preschool years are when the foundations for subsequent development are laid. Otitis media is a prevalent early life health issue. Understanding its impact on children’s development is crucial.Funding proposalsBiodiscovery and biosynthesis of new drug candidates
Less than one percent of the earth’s microbial diversity has been successfully cultivated in a laboratory setting, however the antibiotics and other natural products produced by this small fraction have provided some of the most important medicines in clinFunding proposalsCreating safer workplaces: understanding our work related fatalities
In the aftermath of the catastrophic Pike River Mine explosion New Zealand's poor workplace health and safety record has been under scrutiny.Funding proposalsExploring the development and impact of changes in community pharmacy services
Since the introduction of the New Zealand Primary Health Care Strategy in 2001 there has been a growing emphasis on enhancing primary health care services in order to keep people well within the community and to address health inequalities.Funding proposals