3304 Results
Improving Maori child health outcomes through father involvement
The objective of this study is to contribute to generating an evidence base around Maori father involvement that will lead to improved health outcomes for tamariki.Funding proposalsTu ake Tohea: Measuring Whakatohea whanau wellbeing
Whakatohea whanau have expressed their desire to develop more relevant ways of measuring whanau wellbeing in a manner that considers the broader aspirations of Whakatohea iwi.Funding proposalsRCT of an ICS/LABA reliever therapy regimen in mild asthma
In New Zealand about 20% of adults have asthma, 60% with mild disease. Guideline-based treatment of mild asthma is regular inhaled corticosteroids (ICS), with a short-acting beta agonist (SABA) as a separate inhaler used when needed for symptom relief.Funding proposalsMechanisms and management of musculoskeletal disease
This programme consists of five projects: • A trial (RCT) of zoledronate infusions every 18 months for fracture prevention in women at intermediate fracture risk. • A systematic review of all studies relating calcium intake to fracture risk, to provide a sFunding proposalsEffectiveness of the New Zealand pertussis vaccine schedule
Pertussis remains a global health problem and despite achieving good immunisation coverage New Zealand continues to experience epidemics of pertussis.Funding proposalsCitizen empowerment for creating healthy community environments in New Zealand
Unhealthy diets have overtaken tobacco use as the major risk factor for disease in New Zealand. To date, the pressure for action on reducing obesity and diet-related non-communicable diseases (NCDs) has been predominantly elite (i.e.Funding proposalsSqueezing through cracks reprogrammes cells
DNA folding affects how genes are turned on and off. Despite wide-spread acceptance that this folding is dynamic, little is known about how processes that change cell shape (e.g. migration across membranes) affect genome organisation and cell programming.Funding proposalsCyclic voltammetry of the critically ill: a new window on disease status
Oxidative stress (OS) is a universal feature of acute and critical illness. It occurs when pro-oxidants overwhelm antioxidant defences. There is currently no easy bedside measurement of OS.Funding proposalsDiscovering novel pathways for gout via functional genetics
High levels of uric acid cause gout. Uric acid is made in the blood and levels are regulated by urinary excretion. Drugs that lower uric acid can prevent gout.Funding proposalsTesting a new drug target that promises to impair breast cancer cell growth.
Although breast cancer cells have heterogeneous properties, all of them have a high nutritional demand. The activity of the enzyme Gcn2 is important to meet this demand, thereby supporting cancer cell survival and growth.Funding proposalsIdentifying breast cancer patients with clinically relevant mutations
Identification of cancer-causing mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, has well-defined and actionable implications for disease prevention.Funding proposalsUnderstanding the role of aspirin in breast cancer treatment
Every year, more than 2000 New Zealand women are diagnosed with oestrogen receptor positive breast cancer. Most of these women are treated with therapies that target production or action of the hormone oestrogen.Funding proposalsHaunui, haurua, hauora!
This NKK full grant will iinvestigate Waikato-Tainui rangatahi wellbeing as a result of participation in a developmental voyaging programme which uses traditional navigation and tikanga values and processes.Funding proposalsCatalysts of health and wellbeing: A retrospective study of West Auckland whanau
This research project will look at an urban Maori population’s (West Auckland) experiences and challenges in regards to health and wellbeing.Funding proposalsThe health benefits of karanga
The intent of the study is to investigate the health benefits of karanga for wahine Maori. As a tikanga (cultural norm), karanga is argued to improve health outcomes for Maori women in the domains of wairuatanga, hinengaro, tinana and whanau.Funding proposalsWhole-genome sequencing of drug-resistant Mycobacterium tuberculosis strains for diagnostics and outbreak detection
We will determine the role of whole-genome sequencing (WGS) for drug susceptibility testing (DST) of Mycobactrium tuberculosis in Myanmar and Indonesia, two high TB burden countries.Funding proposalsStress ulcer prophylaxis in the intensive care unit
This study is a large-scale comparative effectiveness study which will establish the safety and efficacy of using proton pump inhibitors versus histamine-2 receptor blockers as the routine strategy for stress ulcer prophylaxis in mechanically ventilated inFunding proposalsDelivering better care for people with severe COPD in the Southern Region
This research aims to improve the healthcare of people with severe chronic obstructive pulmonary disease (COPD) across the Southern DHB region. COPD is a disease of national importance, particularly for Maori. The research has three components.Funding proposalsDevelopment and implementation of an app to support antimicrobial prescribing
The National Quality Improvement Committee has recognised ‘safe medication management’ and ‘infection prevention and control’ as two pressing priorities in healthcare provision.Funding proposalsText4Heart: Improving adherence in people with heart disease
Cardiac rehabilitation (CR), a programme of risk factor education and support, is an essential part of the care of people following a heart attack.Funding proposalsAssociation between Maori cultural identity and health
Existing research confirms the negative effects of colonisation on Maori health. The literature suggests that there is a positive association between cultural identity and health.Funding proposalsTe Ara Ririki
The need for contextualised, culturally safe health/social services is well recognised within Aotearoa, particularly within Mental Health and Addiction Services.Funding proposalsHe Pukenga Korero: Rangatahi and sexually transmitted infections in the Waikato
The aim of this research is to generate an evidence base to inform the development of information resources that will facilitate timely access for rangatahi Maori to STI testing and treatment and thereby improve Maori sexual and reproductive health outcomeFunding proposalsImproving Māori child health outcomes through Māori father involvement
If you want to improve the physical, mental, emotional and social health of Māori children and maintain and build on those early life gains throughout their adolescence and adulthood, the science tells us that you can do it by engaging Māori fathers earlyFunding proposalsKokiritia te Ora: Promoting vitality, enhancing belonging for Ngatiwai tamariki.
In 2012, a wave of youth suicides in Northland featured too many of Ngatiwai descent; this is therefore a major public health issue.Funding proposalsGut peptides post bariatric surgery: mechanisms of adaptive metabolism
Obesity is now a problem of epidemic proportions within New Zealand.Funding proposalsExtending the window of opportunity for saving babies brains
Oxygen deprivation around the time of birth can result in brain damage and lifelong disability. Treatment options for these babies are extremely limited and only partially effective.Funding proposalsUnderstanding GAS pharyngitis and skin infections as causes of rheumatic fever
This research will provide evidence to support improved prevention of acute rheumatic fever (ARF).Funding proposalsThe PLUS trial: PLasmalyte versUs Saline for intravenous fluid therapy in ICU
Fluid resuscitation is a fundamental component of the management of critically ill patients and the choice of fluid is a longstanding issue of debate.Funding proposalsNew generation lipopeptide antimicrobial agents using patented CLipPA technology
Antimicrobial-resistant bacteria has been recognised by the WHO as one of the greatest threats to humankind, and infectious diseases rank as the second most common cause of death worldwide.Funding proposalsNovel biomarker for acute coronary syndromes
Advances in the measurement of troponin in blood using highly sensitive assays has improved time to diagnosis of heart attacks but increases in troponin in patients presenting with chest pain that do not rise above diagnostic thresholds can lead to uncertaFunding proposalsICU-ROX: An ICU RCT of conservative vs. standard OXygen therapy
More than 20,000 New Zealanders (and 20M people globally) are admitted to an intensive care unit (ICU) annually.Funding proposals