3304 Results
The role of microbial viability in regulating mucosal associated invariant T (MAIT) cell activation
Mucosal surfaces are a critical interface with the external environment. The mucosal immune system must be tightly regulated to fight infection while avoiding disease-causing inflammation.Funding proposalsImpact of germline copy number variation on endometrial cancer risk
Endometrial cancer is the most common gynaecological tumour in developed countries, and the incidence of this disease is increasing.Funding proposalsA precision medicine approach to improving heart disease outcomes
Mortality rates for coronary heart disease have fallen over the last 50 years. Patients now live longer following acute coronary events with many surviving to incur later adverse sequelae, especially heart failure.Funding proposalsBLING III - Phase III RCT of continuous β-lactam infusion in the critically ill
Life-threatening organ dysfunction due to infection, is a major cause of mortality worldwide with an estimated 24 million cases and 6 million deaths each year.Funding proposalsInvesting, empowering and enabling adolescents to drive health improvements in Tamaki: A focus on food inscurity in the community
Rates of noncommunicable diseases are steadily rising in New Zealand, particularly in Pacific and Maori populations. Of further concern is the increasing rates of related risk factors in children and adolescents.Funding proposalsHealth-related policies in schools in the Cook Islands
The Cook Islands is burdened with very high rates of noncommunicable disease (NCD) risk among adults and adolescents.Funding proposalsAutomated Insulin Delivery for Type 1 Diabetes utilizing open source technology
Automated insulin delivery (or closed loop technology) for type 1 diabetes has heralded a new era of treatment, delivering improved glucose management and quality of life.Funding proposalsTāne Ora Alliance - Emerging Approaches to Health Gains for Māori Men
Re-orienting mental health programmes to addressing first and foremost the re-connection of Māori men with a culture they can be proud of and a whānau and community within which this cultural identity is safeguarded is key.Funding proposalsA Randomised Controlled Trial of Beta-blockers in COPD
Many patients with chronic obstructive pulmonary disease (COPD) also have heart disease.Funding proposalsA rural-urban classification for NZ health research and policy
The current Statistics NZ definition of “rural” is not designed to be used in health research. When used for this purpose it can compromise efforts to ensure equitable health outcomes and access to health services for rural people.Funding proposalsTwo RCTs of salbutamol therapy in exacerbations of asthma in adults
There is a major burden from asthma in New Zealand, including severe attacks, with over 6,000 hospital admissions due to asthma annually.Funding proposalsThe applicability of ctDNA as a tool for early cancer detection
The burden of cancer among Pacific peoples living in New Zealand and in the Pacific remains a public health concern.Funding proposalsDuration of Dual Antiplatelet Therapy in Acute Coronary Syndrome (DUAL-ACS)
After a heart attack, patients are prescribed two drugs to 'thin' the blood and to prevent further heart attacks.Funding proposalsCan health promotion programs in schools reduce dental caries
There are different types of health promotion programs that may impact on oral health. Generally these fall into two categories: i) Oral Health Education programmes OR ii) Nutrition Focussed Education and Policies.Funding proposalsBiodiversity and microbiota: a novel pathway to allergy and asthma prevention
Asthma prevalence in New Zealand is amongst the highest in the world and there is no cure or effective prevention.Funding proposalsKids'Cam
This study investigates the infectious disease risk factors present in NZ Pacific children's everyday environments.Funding proposalsPharmacokinetics of Benzathine Penicillin G in children and young people in NZ
Benzathine Penicillin G (BPG) has been used as a prophylactic agent against Group A Streptococcal (GAS) infections for over 50 years.Funding proposalsMāori women and abortion: A Kaupapa Māori review
I would like to conduct a review of published literature relating to Māori women and abortion in Aotearoa New Zealand.Funding proposalsRights-based approaches to Māori health: A Kaupapa Māori review
I will be undertaking a literature review that examines rights based approaches as mechanisms for achieving good Māori sexual and reproductive health.Funding proposalsCompilation of Pacific Social Work Resource
To conduct a literature review and compile an annotated bibliography which will be disseminated via the Social Work Regional Resource Center of OceaniaFunding proposalsAre concussion services for mild traumatic brain injury cost effective?
Mild traumatic brain injury (TBI) can no longer be thought of as a ‘low cost’ or ‘short- term’ problem. Associated costs account for a disproportionate cost burden at the macro level, with projected lifetime costs for 2020 more than $89 million.Funding proposalsA suPAR Prognostic Indicator of Cardiovascular Risk and Outcomes
Heart disease remains a leading cause of death in New Zealand. This disease is highly complex and has a substantial component of inflammatory dysfunction.Funding proposalsSensory organisation for balance control in children with strabismus
Strabismus or misalignment of the eyes is a relatively common childhood disorder with an incidence of approximately 4% in children under 6 years of age.Funding proposalsCysteine biosynthesis and infection, gonorrhoea’s weak link?
Neisseria gonorrhoeae is an obligate human pathogen which causes the sexually transmitted infection gonorrhoea.Funding proposalsHospital Operating Theatre Randomised OXygen trial (HOT-ROX)
More than 280,000 surgeries are performed in New Zealand every year. The amount of oxygen given to patients during and after major operations may affect their risk of post-operative complications.Funding proposalsCharactieristics of S. pyogenes isolated prior to rheumatic fever diagnosis
Acute rheumatic fever (ARF) and its serious complication rheumatic heart disease (RHD) are preventable diseases triggered by the bacterium S. pyogenes, more commonly known as a group A strep.Funding proposalsWhangaia ka tupu, ka puawai
‘Whangaia ka tupu, ka puawai’ (That which is nurtured will grow and blossom), involves implementing and testing an augmented clinical care package in a Neonatal Intensive Care Unit (NICU) that standardises culturally responsive care for whānau.Funding proposalsTreatable traits for the management of asthma: a feasibility study
Asthma is a complex condition and people with asthma have differing patterns of disease.Funding proposalsAn epigenetic marker of BCG protection from M. tuberculosis
The Tuberculosis (TB) vaccine, BCG, is the world’s most widely administered vaccine, yet we do not know how its partial protection works. Previously, I have recruited a cohort of TB cases and their household case contacts in Indonesia.Funding proposalsCoaching caregivers of children with developmental disability: A cluster RCT
Occupational Performance Coaching (OPC) is a family-centred intervention that empowers caregivers to support their children to achieve their goals and learn important life skills.Funding proposalsA community-based psychosocial group treatment for older adults with loneliness
Loneliness affects about 10% of older New Zealanders. It is associated with higher death rates and poorer health outcomes. There has been no previous NZ clinical trial on reducing loneliness among older adults.Funding proposalsYounger Women's Wellness after Cancer Program: Feasibility Study
The Younger Women’s Wellness after Cancer Program (YWWACP) aims to improve quality of life and reduce treatment-related chronic disease risk factors in women ≤ 50 years previously treated for breast cancer.Funding proposals