2305 Results
Health Promotion Interventions for Pacific men in a Barbershop
Much has been written about why Pacific men have poor health and wellbeing, but very little is known about what can be done about this in practical terms.Funding proposalsDevelopment of novel prebiotics from marine glycans
Prebiotics are dietary fibre that feed “friendly” gut bacteria and stimulate production of functional metabolites, leading to a healthier digestive system.Funding proposalsRetaining teeth for life: a smart stimuli-response dental pulp medication
Dental caries is a prevalent chronic disease in New Zealand; one in three adults has active dental caries. Caries lead to dental pulp infection, interfering with pulp regeneration and healing.Funding proposalsA hyper-local approach to addressing low immunisation coverage
Vaccines are one of public health's most significant achievements; yet, even with high immunisation uptake overall, geographic clustering of unvaccinated children can lead to outbreaks.Funding proposalsCultured Corneal Endothelial Cells for Endothelial Failure
The human cornea is a transparent tissue that protects the inner contents of the eye, and it refracts light rays focusing them onto the retina. The cornea is prone to trauma, infection, degenerative disorders, and dystrophies.Funding proposalsSelf-signalling mRNA vaccines for sustained antibody immunity
mRNA vaccines have forever changed our approach to fighting infectious diseases like SARS-CoV-2.Funding proposalsScalable heparan sulfate mimetics as dual-mechanism antiviral agents
We urgently need broad-range antivirals that can be rapidly modified and deployed to tackle viral threats. We aim to create and test novel decoy Heparan Sulfate (HS) mimetics for prevention and treatments of viral infections.Funding proposalsBetter rehabilitation: Integration of movement analogies in Māori storytelling
Movement disorders are one of the leading disorders in the world. Effectiveness of motor (re)learning for people with movement disorders is reduced due to disruptions in cognitive processes that are crucial for motor learning.Funding proposalsUsing super-wideband microwave technology to improve cancer early diagnosis
Delays in cancer diagnosis significantly affect the outcomes of cancer treatments.Funding proposalsFeasibility study of feeding time-matched donor human milk to preterm infants
Donor human milk (DHM) is recommended as the next best alternative if the mother’s milk is temporarily unavailable. In New Zealand, preterm infants are fed with pasteurised DHM (PDHM).Funding proposalsCollisions in Junior Rugby: Incidence and magnitude and potential health effect
Rugby union is a popular contact sport played by over 8 million players in 132 countries. In New Zealand 80% of active rugby players are juniors.Funding proposalsUsing multimodal MRI, genomics and AI to tackle ethnicity bias in neuroimaging
Technological advancements in machine learning and brain-MRI big data have led to rapid development of neuroimaging biomarkers useful for neurological/psychiatric disorders (e.g., Alzheimer’s and schizophrenia).Funding proposalsPreventing the ups and downs of lithium in bipolar disorder
Lithium is the gold-standard treatment for bipolar disorder and the only medication to reduce suicide risk. However, its effective dose is close to the toxic dose and frequent blood monitoring is required to prevent poisoning.Funding proposalsPositively selecting your MAIT Cells
Mucosal-associated invariant T (MAIT) cells are immune cells that provide immunity against bacterial, fungal, and viral pathogens, but when dysregulated have been implicated in cancer, inflammation and autoimmune diseases.Funding proposalsGuided by Hine te Iwaiwa: Exploring Maramataka influence on pregnancy outcomes
This research aims to explore the effects of incorporating the maramataka, a traditional Māori lunar calendar system guided by the goddess Hine te Iwaiwa, into the context of pregnancy care for wāhine Māori and Māori midwives.Funding proposalsIntergenerational Trauma Healing for Gang Wāhine & Kōtiro
Gangs in Aotearoa have evolved over four generations into distinct gang whānau with mokopuna and great mokopuna born into them. Gang whānau are some of the most marginalised and discriminated against communities in Aotearoa.Funding proposalsElucidating pathways of kidney injury and repair – new therapeutic options?
With Professor Ding and colleagues at the Department of Nephrology, Zhongshan hospital, Fudan University, Shanghai, China, we plan to set up a collaborative research project elucidating mechanisms of kidney injury and repair to identify new therapeutic optFunding proposalsFrom health crisis to balance: Evaluation of a national Falls Prevention Pathway
As our population ages rapidly, falls in community dwelling older persons, already highly prevalent, are expected to dramatically increase demand on New Zealand’s Emergency Medical Services (EMS).Funding proposalsMinimally-invasive gastric ablation for GI disorders
Gastrointestinal (GI) disorders affect up to 30% of the world’s population, causing substantial clinical, societal, and economic burdens. Treatment options for these disorders are limited, causing frustration for patients and clinicians alike.Funding proposalsOptimising immunotherapy for Māori with advanced non-small cell lung cancer
Lung cancer is the leading cause of cancer death in New Zealand, with Māori suffering the highest incidence and death rate. Immunotherapy significantly improves survival in advanced lung cancer and was funded to treat New Zealanders in April 2023.Funding proposalsRandOmised Arthroplasty infection worlDwide Multidomain Adaptive Platform Trial
19,300 hip or knee replacements are performed in Aotearoa every year. The lifetime risk of a prosthetic joint infection (PJI) is 2% and so many New Zealanders are diagnosed with PJIs each year.Funding proposalsIncreasing cardiac vagal activity as a novel treatment for heart failure
People living with heart failure have severely impaired quality of life because even day-to-day menial activities leave them breathless and incapacitated.Funding proposalsMapping childhood immunity to Strep A
Group A Streptococcus (Strep A) causes a range of diseases from acute pharyngitis (Strep throat) to life-threatening invasive infections and rheumatic fever (RF).Funding proposalsTranslational 'omics of the hidden genome for equitable precision medicine
Cardiometabolic diseases (e.g.,type 2 diabetes, chronic kidney disease and gout) are increasing in prevalence worldwide at an alarming rate.Funding proposalsReturning to productive life and work: an investigation of the impacts of cancer
This research aims to investigate how cancer impacts the productivity of survivors, and identify ways to better support survivors in their return to work and other productive activities.Funding proposalsEvaluation of the implementation of decentralised clinical trial methodology
There is currently wide geographic variability in access to oncology clinical trials in New Zealand, with smaller hospitals and rural New Zealand having least access. Clinical trials are important to improve outcomes for patients with cancer.Funding proposalsBeyond the pandemic: Applying complexity science in child immunisation services
Routine childhood immunisation rates have been suboptimal and have further decreased since the onset of the Covid-19 pandemic, thereby exacerbating pre-existing immunisation inequities by ethnicity and region.Funding proposalsProtecting Mum: hormone-driven neural plasticity to regulate mood and behaviour
Healthy growth and development of new-born infants requires significant investment in care-giving by mothers.Funding proposalsExploring the mental health impacts of climate change on kai sovereignty
Global climate change will undermine public health initiatives and outcomes at population levels, and the ability to grow and gather food is a critical dimension of this challenge.Funding proposalsTe Hao Hou: Rangatahi Māori experiences and perceptions of smoking and vaping
There is rising concern about burgeoning vaping rates among rangatahi, in particular rangatahi Māori. Government policies have done little to address risk of rangatahi taking up vapes.Funding proposalsREMAP-CAP: Improving treatment for pneumonia, influenza and pandemic infections
Severe pneumonia is common, especially for Māori who also have more complications after hospital discharge. REMAP-CAP identifies optimal treatments for severe pneumonia and influenza and can quickly adapt for a pandemic.Funding proposalsLifecourse Trajectories for Young Pasifika in Aotearoa (PIF: ATP)
The Pacific Islands Families (PIF) birth cohort study is a successful and unique longitudinal investigation of Pacific infants born in South Auckland, Aotearoa (NZ) in 2000 (n=1398).Funding proposals