Lay summary
Pancreatic cancer is highly aggressive, with a poor five-year survival rate despite advancements in treatment over recent decades. Furthermore, Māori face disproportionately higher pancreatic cancer mortality compared to non-Māori. Precision medicine development plays an important role in addressing these issues. Yet, current international molecular data on pancreatic cancer does not reflect New Zealand's ethnic diversity. We propose a comprehensive genomic analysis of pancreatic cancer specimens from Te Ira Kāwai (Auckland Regional Biobank) and purposefully interpreting Māori pancreatic cancer genetic data using frameworks that honour Te Tiriti o Waitangi and its commitment to ongoing partnership with Māori. We will also collect new specimens by establishing a pancreatic cancer focused biobank in collaboration with Te Ira Kāwai. By deepening our understanding of pancreatic cancer at a genetic and immunological level, we aim to improve pancreatic cancer survivability, address Māori health inequities and increase representation of Māori in the field of precision oncology.