3304 Results
Low OxyGen Intervention for Cardiac Arrest Injury Limitation (LOGICAL) Trial
This randomised clinical trial will test the hypothesis that using a conservative oxygen therapy regimen instead of a standard liberal oxygen therapy regimen reduces brain damage and improves survival with a good recovery in adults who are in a coma followFunding proposalsIMPEDE-PKD: Metformin to protect kidney function in polycystic kidney disease
IMPEDE-PKD is a clinical trial evaluating whether metformin prevents kidney failure in people with polycystic kidney disease (PKD). PKD is a genetic condition causing large kidney cysts.Funding proposalsConnected: Who benefits from online delivery of mental disorder treatment?
Early treatment of mental disorders is essential to reduce suffering and to decrease early mortality. Most prevalent among rangatahi aged 16-24, untreated mental disorder affects relationships, education, and career options.Funding proposalsProtecting the lungs of the critical illness patient
Key to managing many patients with significant illness is the preservation of sufficient oxygen delivery. When patients are very unwell this process can become compromised and mechanical ventilation is required.Funding proposalsFighting leukaemia colonisation of the haematopoietic niche
Acute myeloid leukaemia (AML) has a low survival rate of 22% in NZ. Treatment options for AML are limited and new strategies are needed to combat this disease.Funding proposalsDevelopment of a targeted drug therapy for acute kidney injury
Acute kidney injury, caused by various insults including bacterial and viral (COVID19) infections, nephrotoxic drugs, and reduced blood flow, is associated with significant mortality and risk of developing chronic kidney disease.Funding proposalsEffect of an Aotearoa NZ Diet for metabolic health on the gut microbiome
Will the consumption of an Aotearoa NZ Diet that includes a preponderance of plant-based foods, together with lean protein (seafood, lean red meat, and dairy), offer health benefits to people at risk of cardiometabolic disease?Funding proposalsA novel intracranial baroreceptor mechanism for blood pressure control
We discovered a novel baroreceptor located inside the brain - ‘intra-cranial’ that senses physiological changes in cerebral blood pressure.Funding proposalsTrial halves respiratory infections in children
An HRC-funded trial to test the effectiveness of the drug azithromycin (AZM) on Māori and Pacific children with bronchiectasis – a type of irreversible scarring in the lungs – has achieved a 50 per cent drop in respiratory infections.NewsKetamine versus Ketamine plus Behavioural Activation Therapy for Depression
Major Depressive Disorder (MDD) is the most common psychiatric disorder. Usual treatments for MDD have limitations including side effects and inadequate response rates.Funding proposalsNgā Hau o Tāwhiri - Returning our Mokopuna to the Winds of Tāwhiri
Similar to the situation for Indigenous children and young people worldwide, mokopuna Māori experience unjust incarceration on a mass scale in New Zealand.Funding proposalsWaerea: Māori whānau experiences of assisted dying in Aotearoa New Zealand
The Waerea end-of-life study investigates whānau Māori (n=40) experiences of accessing and using assisted dying (AD).Funding proposalsTaunakitanga Takitini: reframing self-management support for all in Aotearoa
Taunakitanga Takitini programme aims to build Aotearoa specific knowledge about supported self-management to enable those who experience greatest health inequities, that is, underserved populations living with lifelong conditions (specifically Māori and PaFunding proposalsTranslating biophysical models for heart health
Heart disease remains the leading cause of death in Aotearoa New Zealand, with many deaths being preventable and premature.Funding proposalsImpact of Dementia mate wareware and Solutions for Equity in Aotearoa: IDEA
The combination of increasing numbers of older people and age being the strongest risk predictor makes dementia (mate wareware) a significant population health investment.Funding proposalsTranslational advances in GI surgical recovery and motility disorders
Disorders of gut function impart a massive global burden of ill health, decreased quality of life, lost productivity, and add billions of dollars in healthcare expenditure.Funding proposalsInvestigating the functions of p53 isoforms and their clinical translation
This programme focusses on understanding how the TP53 gene network, especially p53 isoforms, contributes to cancer, and using this information to develop clinically useful information and tools.Funding proposalsWhakatipu Rakatira: improving sleep as a vehicle to grow healthy future leaders
We all know the value of a good night’s sleep. Yet, for many reasons, good sleep health is often not prioritised, meaning many children and adolescents do not get enough good-quality sleep that lets them function well in today’s busy world.Funding proposalsWhakatōmuri, whakamua: Walking backwards into the future of Māori cancer care
Māori have poorer cancer survival for 23 of the 24 most common cancers diagnosed in NZ. There is evidence that Māori are less likely to receive best-practice care during their cancer journey, and this may contribute to these unacceptable differences.Funding proposalsAction needed on poor Māori oral and dental health
More needs to be done to improve the oral health of Māori.NewsBetter patient care at heart of NZ's $35M spend on new research programmes
Research to eradicate inequities in cancer survival for Māori has gained funding from the Health Research Council of New Zealand (HRC). It’s one of several five-year research programmes awarded a combined total of $35 million announced today.NewsMana Mōmona: Exploring Fat (Bias) within Health Spaces for Māori
Fat bias is pervasive in healthcare and has life threatening implications for fat people, particularly for fat Māori who must navigate multiple systems of oppression.Funding proposalsOutcomes for tamariki with acute rheumatic fever in Counties Manukau
Despite the high incidence of ARF in Aotearoa and Counties Manukau, there is little information either in published medical literature or accessible to the general public, about the clinical features, management and long-term health outcomes of children inFunding proposalsSocial media transparency statement
This transparency statement outlines the Health Research Council of New Zealand’s (HRC) approach to using and managing social media.ResourceHRC Update 7 July 2023
NewsHRC Update 27 July 2023
NewsThe Lotu Factor: Delusional Religiosity, Covid-19 and Tongan Wellbeing in NZ
During the COVID-19 pandemic, health professionals encountered some objections and resistance from the Pacific communities.Funding proposalsUtility of dietary management for ulcerative colitis
Evidence from the literature suggests that diet is a promising means to manage inflammatory intestinal disorders such ulcerative colitis (UC). However, guidance for the use of nutrition therapy in UC is lacking in the NZ healthcare sector.Funding proposalsInaugural HRC Beaven Medal presented to innovative Canterbury health researcher
The inaugural HRC Beaven Medal for excellence in translational research was presented to Dr Martin Than, a consultant specialist in Emergency Medicine at the Canterbury District Health Board, for research that will provide an innovative and workable chaNewsCan we provide a better 'Healthy Lungs' Programme?
The aim of this placement is to partner with the Healthy Lungs Study, a longitudinal study focusing on early respiratory infection in tamariki Māori and Pasifika children and subsequent respiratory disease in later years.Funding proposalsMatauranga o Mate Huka - Creation of type 2 diabetes resources in the Waikato
Māori populations are disproportionately affected by type 2 diabetes (T2D). They are 2.5 times more likely to receive a diagnosis than non-Māori and are more likely to experience suboptimal glycaemic control and long-term complications.Funding proposalsEndometrial Cancer Microbiome Study
Significant health and equity issues exist in endometrial cancer (EC; womb or uterus cancer) incidence and mortality for Māori and Pacific women in Aotearoa.Funding proposals