3309 Results
Hepatitis B, Diabetes and Outcomes
This is a research project of the interaction between chronic hepatitis B infection, a communicable disease and type II diabetes, a non-communicable disease of the affluent world.Funding proposalsThe role of the Pax-Notch pathway in kidney disease
Chronic kidney disease (CKD) is rising in New Zealand at an alarming rate, particularly in the Maori and Pasifika, and new treatments are urgently needed. Podocytes, the blood filtering cells in the kidney, die or are damaged in >90% of CKD cases.Funding proposalsGene discovery in epilepsy: the building block of precision medicine
Epilepsy, which affects 0.5% of the population, is the most common serious neurological illness of children and young people.Funding proposalsThe New Zealand International Tobacco Control Project
We will initiate a New Zealand arm of the ITC project - a leading international tobacco control collaboration.Funding proposalsRegistry based clinical trials
Clinical trials provide the most reliable evidence to determine which treatments benefit patients. However, randomised trials are logistically difficult to undertake and very expensive.Funding proposalsHypertension after stroke - therapeutic or pathological?
Because we lack a full understanding of how and why the brain responds to the reduced blood flow and low brain oxygen that occurs during a stroke, it is not known whether it is beneficial to treat the rise in blood pressure commonly seen in patients immediFunding proposalsLung cancer genetic testing in New Zealand
Lung cancer is a major cause of death in New Zealand, disproportionately so for Maori and Pacific people.Funding proposalsSubsequent Injury Study (SInS): Improving outcomes for injured New Zealanders
Subsequent injury (SI; sometimes referred to as re-injury or being ‘accident prone’) is a major contributor to the global injury disability burden. Last year, New Zealand’s injury insurer (ACC) spent $2.9 billion and received 1.8 million injury claims.Funding proposalsProbing novel pathways mediating polycystic ovarian syndrome
Fertility is controlled by a network of neurons within the brain.Funding proposalsCellular reprogramming: A unique approach to understanding Huntington's disease.
Huntington’s disease (HD) is a genetic neurological disorder that results in severe motor deficits due to loss of striatal medium spiny neurons (MSNs) in the brain. Inaccessibility to live human neurons is a major barrier to studying HD.Funding proposalsSafety on steps: a randomised controlled trial
Of all ACC claims for injury in the home, almost half are falls (loss of balance or slipping).Funding proposalsTARGET (The Augmented versus Routine approach to Giving Energy Trial)
TARGET is a 4000-patient, multicentre, double-blinded, randomised controlled clinical trial designed to determine if delivery of the full-recommended calorie (energy) requirement to critically ill patients via a feeding tube improves 90 day survival when cFunding proposalsTe whakahawea tangata: decoding discimination
Approaches to Maori health recognise the connectedness of individuals and collectives, both with each other and with their environments (physical and non-physical).Funding proposalsAspirin harm benefit calculator to guide cardiovascular primary prevention
Aspirin reduces the risk of heart attacks and strokes but also increases the risk of bleeding.Funding proposalsTeeVax - a novel vaccine against group A streptococcus?
Streptococcus pyogenes, or group A streptococcus (GAS), is a bacterium that causes a wide range of human diseases, including pharyngitis, toxic shock and acute rheumatic fever.Funding proposalsPrehospital injury deaths: preventability, service accessibility and equity
Injury is a major cause of premature death in NZ. Injury outcomes are time-sensitive with many deaths occurring prehospital (at the scene/in transit).Funding proposalsThe combined use of nicotine replacement therapy and e-cigarettes
Smoking is a leading cause of death and disability in New Zealand, with clear ethnic and social class differences.Funding proposalsA healthy life starts with a bio-energetically healthy placenta
For nine months we absolutely rely on our placenta functioning correctly. The placenta carries out the functions of the kidneys, lungs, gut and liver of an adult yet it is poorly studied.Funding proposalsDoes preventing neonatal hypoglycaemia improve outcome at two years of age?
Hypoglycaemia (low blood glucose concentration) is common, and the only readily preventable cause of brain damage in newborn babies.Funding proposalsInvestigating a novel drug target in acute myeloid leukaemia
It is rare to identify completely new genetic pathways that lead to cancer. However, the incentive to do so remains strong, to identify novel opportunities for therapeutics.Funding proposalsCarrageenan for the reduction of asthma exacerbations in adults
New Zealand has high rates of asthma and hospitalisations for asthma. Viral respiratory infections are the most common cause of asthma exacerbations in both children and adults.Funding proposalsThe chemoprevention and treatment of diffuse gastric cancer
We have previously identified a panel of drugs which preferentially kill cancer cells that are deficient in the cell-to-cell adhesion protein E-cadherin.Funding proposalsEnabling participation for children and young people with disabilities
Children and young people with disabilities face substantial barriers to access and inclusion, with major implications for health and wellbeing.Funding proposalsOlder drivers, families and GPs: Navigating the path between mobility and safety
Most older New Zealanders travel by private car and continuing to drive is key to mobility, independence and quality of life. Giving up driving can have serious negative consequences for older people’s health and wellbeing.Funding proposalsThe impact and management of rising osteoarthritis burden
Osteoarthritis (OA) affects around 40% of adults >45 years, resulting in an enormous economic and disability burden on individuals and society.Funding proposalsOral health from childhood to mid-life
We propose to investigate how dental health changes from childhood to age 45 years.Funding proposalsThe gut microbiome: a new pathway to obesity prevention and metabolic health
The prevalence of obesity has increased substantially over recent decades and interventions to halt the epidemic have been unsuccessful.Funding proposalsSelf-directed rehabilitation RCT after stroke: a practical, low-cost programme
Self-directed rehabilitation, using a ‘Take Charge session’, has been shown to be a powerful, practical, low-cost strategy for improving outcomes for Maori and Pacific people after stroke.Funding proposalsMitochondrial injury and inter-cellular mitochondrial transfer
One of the most striking recent discoveries in cell biology is that organelles such as mitochondria move between cells.Funding proposalsPersistent airflow limitation and the airway microbiome in childhood asthma
This study will determine if airway microorganisms are associated with lung function deficits and non-allergic inflammation in childhood asthma.Funding proposalsWhakapai e te Ara Hä: A health literacy approach to tamariki asthma
Asthma currently affects 26% of New Zealand children, a rate that is amongst the highest in the world. The inequalities in asthma outcomes for Maori tamariki are striking, and have increased in recent decades.Funding proposalsCaMKII inhibition as a novel therapy for diabetic cardiomyopathy
The incidence of diabetes mellitus in New Zealand and the world is reaching epidemic levels, creating a substantial burden on personal health and medical cost for the public.Funding proposals