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Timekeeping in the neural network controlling fertility

50 months
Approved budget:
Health issue:
Reproduction/fertility/sexual health
Proposal type:
Lay summary
Fertility is controlled by a complex neuronal network in the brain that drives the activity of the gonadotropin releasing hormone (GnRH) neurons. This project aims to examine the mechanisms underlying the regulation of this neuronal network by the central biological clock in females. We will use state-of-the art experimental approaches in mouse models to dissect the specific brain circuits involved in keeping time within the GnRH neural network under both physiological and pathological conditions. We anticipate our studies will provide new information of the brain mechanisms involved in the control of reproductive function, and may open new avenues for therapeutic strategies for treating infertility in the clinic.