3304 Results
Bi-modal anti-Müllerian hormone signalling in the ovary.
Anti-Müllerian hormone (AMH) is an ovarian regulator of egg development and appears to contribute to conditions of infertility.Funding proposalsImproving patient safety in New Zealand general practice
Over 90% of New Zealand healthcare interactions occur in primary care, but 16% of patients are harmed by the care they receive. Patient harms cost everyone; patients, their whanau, workplaces and the health system.Funding proposalsHeart samples collected by Heart Otago- the link to pacific populations.
From 2006 to 2007, 10 percent of Pacific peoples aged over 15 years were diagnosed with diabetes – approximately three times the diagnosis rate for the total New Zealand population (Statistics New Zealand and Ministry of Pacific Island Affairs, 2011).Funding proposalsUnder the knife: Why are Maori more likely to die shortly after surgery?
A national committee that monitors death after surgery have estimated that Maori are 62% more likely to die within 30 days following an elective or waiting list procedure - even after taking age, gender, deprivation and physical status into account.Funding proposalsDevelopment and application of a risk prediction tool for emergency laparotomy
Emergency laparotomy is a commonly performed surgical procedure with a high mortality and morbidity. Several different operations can be classified as an emergency laparotomy and are commonly performed on acutely unwell patients as a lifesaving procedure.Funding proposalsManagement of psychological factors after mild traumatic brain injury
Concussion is very common and topical in New Zealand, with more than 30,000 New Zealanders sustaining concussions annually.Funding proposalsGenetic characterisation of the epileptic encephalopathies
The epileptic encephalopathies (EE) are a devastating group of epilepsies where frequent seizures result in neurological damage.Funding proposalsMental health and well-being of Pacific youth in higher education
The mental health of Pacific young people in New Zealand is a concern. Mental health is included in the New Zealand Health Research Strategy as an area of priority.Funding proposalsLong term outcomes of children born at risk of neonatal hypoglycaemia
I'm conducting research into the effect of low blood glucose concentration in the newborn period, and of the maternal metabolism during pregnancy on the neurodevelopment of children.Funding proposalsDevelopment of novel remyelination treatments for Multiple Sclerosis
New Zealanders have one of the highest rates of Multiple Sclerosis (MS) in the world. It is a debilitating neurological disease with no cure.Funding proposalsEthnic Discrimination Prevalence and Health Associations in NZ Youth
Research has shown that ethnic discrimination is more commonly reported by minority groups within society.Funding proposalsDeveloping a gut dysfunction scoring tool in critical illness
Gastrointestinal (gut) dysfunction/failure (GDF) is a common problem in acute and critically ill patients.Funding proposalsDeveloping an optimal strategy for the rheumatic fever endgame
Acute rheumatic fever (ARF) and its serious complication, rheumatic heart disease (RHD), produce large ethnic health inequities and remain important causes of preventable suffering and death for Maori and Pacific New Zealanders.Funding proposalsOptimising parent-child interaction therapy for childhood conduct problems
Some children have challenging behaviour that lasts beyond the ‘terrible twos’ and begins to have serious consequences, with difficulties that continue into adulthood.Funding proposalsThe prognostic significance of immune cell infiltrates in meningioma
Meningiomas are tumours that arise from the coverings of the brain. Often regarded as ‘benign’, meningiomas can compress important parts of the brain - causing permanent disability (e.g. blindness) or death through uncontrolled growth.Funding proposalsProcess evaluation of trials: maximising the potential for implementation
Musculoskeletal disorders are the second largest cause of disability worldwide. In New Zealand, the burden of musculoskeletal disorders is very high.Funding proposalsThe role of a sublingual bacterial vaccine in adult bronchiectasis patients.
Bronchiectasis is a chronic, debilitating disease characterised by productive cough, airway inflammation and repeated respiratory infections. It disproportionately affects Maori and Pacific peoples in New Zealand.Funding proposalsImpact of microenvironment on dendritic cell function
Understanding host-pathogen relationships is key in the rational design of vaccines that prevent disease and improve the health and wellbeing of all individuals.Funding proposalsPathways to first episode psychosis and outcomes in Maori
There is some evidence of Maori having increased prevalence and worse outcomes following diagnosis a psychotic disorder. However, little is known about the factors contributing to these inequities or strategies to reduce them.Funding proposalsTongan children's nutrition - native vs. NZ migrants
An investigation into the similarities and differences between the diets of Tongan children in Tonga and Tongan children in New Zealand.Funding proposalsRandomised controlled trial of prescription charges
Although prescription charges in New Zealand are low compared with many other countries, many people report that they cannot afford the medicines they need.Funding proposalsCo-design of a pilot mental wellbeing initiative for Pacific tertiary students
The aim of this project is to develop a pilot mental wellbeing initiative specifically by, and for, Pacific tertiary students. To help inform this process, focus groups and key informant interviews with campus student support personnel will be undertaken.Funding proposalsDo regional District Health Board (DHB) groupings improve service integration and health outcomes?
This research aims to improve health care for New Zealanders through studying the four regional District Health Board (DHB) groupings which together cover all of New Zealand (NZ).Funding proposalsEpigenomic profiling to predict patient response to melanoma immunotherapy
The recent developments of cancer immunotherapies that target immune checkpoint proteins are demonstrating durable clinical success for melanoma patients.Funding proposalsReducing fatigue after stroke: A randomised controlled trial
Fatigue is a common and persistent deficit in up to 92% of stroke survivors that can negatively impact functioning. It is imperative that new strategies be developed to address post-stroke fatigue, a debilitating but often overlooked sequelae of stroke.Funding proposalsUnderstanding regulation of the Polycomb Repressive Deubiquitinase in malignancy
Reversible modifications to histone proteins play a major role in histone-DNA packaging and ultimately gene expression. The Polycomb Repressive Deubiquitinase (PR-DUB) complex removes one important type of histone modification.Funding proposalsIs prophylaxis required with start-low go slow dosing of allopurinol in gout?
Long-term urate lowering is key to successful treatment of gout. However, commencing urate lowering therapies, particularly when starting higher doses, is associated with painful attacks of gout.Funding proposalsTreating cognitive impairment in severe depression
Patients with severe depression admitted to an in-patient psychiatric unit have a high risk of suicide, poor recovery, frequent re-admission and serious problems with cognitive function (memory, concentration, planning) leading to difficulties in employmenFunding proposalsTowards a new penicillin for rheumatic fever - the BPG pharmacokinetic study
Acute rheumatic fever (ARF) is an autoimmune condition caused by untreated group A streptococcal (GAS) infection of the throat and possibly skin. Multiple or severe attacks of ARF can cause permanent heart damage known as rheumatic heart disease (RHD).Funding proposalsThe effectiveness of circuit-based exercise in Cook Islands communities
The proposed research is a physical activity intervention that will take place in Cook Island communities of both New Zealand and within the Cook Islands.Funding proposalsNew horizons for preterm brain protection: exploiting endogenous neuroprotection
Many preterm infants develop brain injury around the time of birth, with a high risk of life-long disability. Currently, we have no effective way of preventing disability.Funding proposalsTargeting chemoreceptors in hypertension: a large animal pre-clinical trial
High blood pressure (hypertension) affects one third of the adult population in New Zealand causing strokes and heart disease. Only half of these patients have blood pressure adequately controlled because of ineffective treatment.Funding proposals