2305 Results
Glucoregulation by leptin: The missing piece to the puzzle of tissue repair?
It is well known that individuals with obesity or type 2 diabetes have severely impaired tissue repair, but the underlying mechanisms are largely unknown.Funding proposalsPumping gas the right way
Inability to sufficiently breath and to provide the body's oxygen need is very common in a wide range of critical illness states. More recently high profile illness states such as covid-19 have seen a dramatic rise in the use of mechanical ventilation.Funding proposalsNovel approaches to support patients in acute settings
The current interest in respiratory failure due to COVID-19 has focused interest in solutions to improve outcomes when patients are on prolonged periods of oxygen supplementation and ventilation.Funding proposalsThe warfare between bacteria and bacteriophage, its benefits to humankind
The aim of the project is to identify natural antiviral compounds against human viruses by activating the bacterial immune system.Funding proposalsA nationwide strategy to improve lung cancer outcomes with molecular testing
Lung cancer mortality is particularly high in NZ, with stark inequities adversely affecting Māori and Pasifika. As poor outcomes result from diagnosis at late stage, earlier detection would improve patient survival.Funding proposalsCumulative impacts of air pollution exposure on adult physical and mental health
Air pollution is recognised as a cause of morbidity but its longer-term and cumulative effects on health are less established. In New Zealand, persistent health inequities exist for Māori who are exposed to poorer environments than non-Māori.Funding proposalsImproving population health through education of the innate immune system
Reduced exposure to microbial products and pathogens in early life through increased hygiene and urbanisation has been associated with increased prevalence of disorders related to immune dysfunction, including inflammatory and allergic diseases and autoimmFunding proposalsDevelopment of an ultrasound responsive implant to treat spinal cord injury
Spinal cord injury is devastating and incurable with a relatively high prevalence in New Zealand. Growth factors are known to help recovery, although it is not currently possible to deliver appropriate amounts to the site of injury.Funding proposalsA data-driven approach to predicting asthma attacks in Aotearoa
Asthma is one of the most common long-term conditions in New Zealand (NZ), affecting 1 in 5 children and 1 in 8 adults. Asthma attacks are the leading cause of asthma deaths, placing a significant burden on our health system.Funding proposalsExploring the role of the inflammasome pathway in diabetic retinopathy
Diabetes is one of the most common health problems in New Zealand affecting over 250,000 New Zealanders. It is associated with several complications, one of which is diabetic retinopathy (DR), a chronic disease that can lead to vision loss.Funding proposalsModelling procalcitonin for bacterial infections in intensive care
Over 14,000 patients are admitted to intensive care each year in Aotearoa. About half will develop infections.Funding proposalsOlder informal caregiver experiences following the COVID-19 pandemic in Aotearoa
Informal caregivers play a vital role in the healthcare and social services in Aotearoa. However, their unpaid labour is undervalued, and challenges associated with caregiving during the pandemic are understudied.Funding proposalsTreating gastric cancer according to its biology
Cancers originating from the same anatomical location often display distinct characteristics, which influence their interaction with the immune system, the success of treatments and patient survival.Funding proposalsInvestigating fibroblast influence on the gastric cancer microenvironment
Gastric cancer is more than one disease, having two main subtypes that show markedly different appearances microscopically, yet it is treated as one disease.Funding proposalsInvestigating the diet-microbiome connection in paediatric coeliac disease
Coeliac disease is an autoimmune disease that occurs in 1/82 Cantabrians - one of the highest rates in the world, making Canterbury an interesting place to study coeliac disease.Funding proposalsMenstrual cycle status and iron deficiency diagnosis in healthy females
This project aims to examine the changes in menstrual cycle status, primarily bleeding characteristics in healthy regularly menstruating premenopausal females in response to psychological stress and dietary intake.Funding proposalsImplementing effective lifestyle treatment for T2 Diabetes in primary care
Type 2 Diabetes (T2D) and prediabetes (PD) are a major challenge for the NZ health system. Disproportionately affecting Māori and Pacific people, it is a leading driver in health inequalities.Funding proposalsDelivering optimal weight gain advice to pregnant women (DOT) study
Unhealthy weight gain in pregnancy is common in Aotearoa/New Zealand (up to 70% of pregnant women). It increases the risk of adverse outcomes e.g. gestational diabetes and large for gestational age babies.Funding proposalsMeasuring the impact and social value of Turanga Health's services
How can Māori health providers measure the impact and social value of their activities in complex environments? Can a tool such as Social Return on Investment (SROI), developed overseas, be useful in a kaupapa Māori setting?Funding proposalsPae Ora - collaborations in action
We will undertake a mixed-methods evaluation of Whakamaua: Māori Health Action Plan 2020-2025, which will embed Te Tiriti o Waitangi and Mātauranga Māori to ensure translational research that addresses the outcomes, objectives and potential future directioFunding proposalsThe impact of nitrate in drinking water on preterm birth
This research will investigate the association between nitrate in drinking water and preterm births.Funding proposalsHe rapunga hauora mō te mate wareware: A prevalence study
The health and wellbeing of our kaumātua/pākeke is under threat. Māori have a higher prevalence of risk factors for mate wareware and therefore are more likely to suffer from this disease.Funding proposalsThe CALCRL receptor: A new genetic determinant of diabetic kidney disease in New Zealand
Diabetic kidney disease is a major health issue in New Zealand. Māori and Pacific people are particularly affected, with genetics being a likely component of this inequity.Funding proposalsA randomised controlled trial of a low dose serotonergic agonist for depression
Mood disorders are a leading cause of health loss in New Zealand, however, current treatments do not work or are not well tolerated by a large number of people who suffer from these disorders.Funding proposalsTIAKI – Community wellbeing for whānau with lived experience of incarceration
As experienced by Indigenous peoples globally, Māori experience unjust mass incarceration, impacting on the health and wellbeing of not only those who are incarcerated but their whānau and communities.Funding proposalsAdvancing palliative care among Pacific children
Palliative care in Aotearoa New Zealand (NZ) aims to support quality of life until death, while also supporting family, whānau, and caregivers throughout this process, often into bereavement.Funding proposalsEarly brain development and later outcomes in moderate-late preterm babies
Babies born preterm are at increased risk of impaired lifelong health and wellbeing.Funding proposalsHe Toa Taumata Rau - The Many Resting Places of Courage
Transition from military to civilian life can be a critical period for Māori veterans and a challenging time for their whānau (Perlick et al., 2017).Funding proposalsNovel biomarker validation to guide treatment in inflammatory bowel disease
Inflammatory bowel disease (Crohn's disease and ulcerative colitis) are common in New Zealand. There is no cure and young people live with severe gut symptoms such as pain, diarrhoea, weight loss and bleeding.Funding proposalsGenomic epidemiology of human respiratory viruses in Aotearoa
New Zealand’s interventions to control COVID-19 have eliminated respiratory viruses that ordinarily circulate annually.Funding proposalsWhānau-centric coronial processes to improve suicide prevention strategies
The high rates of rangatahi (Māori youth) suicide provide one of the starkest social and health disparities that exist between Māori and non-Māori. This project builds on a research activation grant that investigated coronial processes and how these can bFunding proposalsHow can we improve eye, hearing and feet health for kaumātua/older adults?
Older adults commonly experience sensory impairment due to their eye, hearing or foot health, particularly if they also live with diabetes.Funding proposals