2376 Results
Is prophylaxis required with start-low go slow dosing of allopurinol in gout?
Long-term urate lowering is key to successful treatment of gout. However, commencing urate lowering therapies, particularly when starting higher doses, is associated with painful attacks of gout.Funding proposalsTreating cognitive impairment in severe depression
Patients with severe depression admitted to an in-patient psychiatric unit have a high risk of suicide, poor recovery, frequent re-admission and serious problems with cognitive function (memory, concentration, planning) leading to difficulties in employmenFunding proposalsTowards a new penicillin for rheumatic fever - the BPG pharmacokinetic study
Acute rheumatic fever (ARF) is an autoimmune condition caused by untreated group A streptococcal (GAS) infection of the throat and possibly skin. Multiple or severe attacks of ARF can cause permanent heart damage known as rheumatic heart disease (RHD).Funding proposalsThe effectiveness of circuit-based exercise in Cook Islands communities
The proposed research is a physical activity intervention that will take place in Cook Island communities of both New Zealand and within the Cook Islands.Funding proposalsNew horizons for preterm brain protection: exploiting endogenous neuroprotection
Many preterm infants develop brain injury around the time of birth, with a high risk of life-long disability. Currently, we have no effective way of preventing disability.Funding proposalsTargeting chemoreceptors in hypertension: a large animal pre-clinical trial
High blood pressure (hypertension) affects one third of the adult population in New Zealand causing strokes and heart disease. Only half of these patients have blood pressure adequately controlled because of ineffective treatment.Funding proposalsPharmacological brain-imaging of novel rapid antidepressant medicines
Major depression is the leading cause of disability-related health loss in the western world with an annual economic cost to New Zealand of $2 billion.Funding proposalsDoes inhibition of quorum sensing increase antibiotic resistance spread?
Infectious disease is a re-emerging global challenge with a disproportionate burden in Maori compared to non-Maori. Furthermore, this problem is exacerbated by an increase in antimicrobial resistance and limited discovery of new antibiotics.Funding proposalsTargeting new receptors for lipoprotein(a)
Twenty percent of people have high plasma levels of a form of cholesterol called 'Lp(a)' which predisposes them to heart attacks.Funding proposalsEffects of artificial sweetener in the maternal diet on offspring fertility
There is evidence that artificial sweeteners, as found in ‘diet’ or ‘light’ options, increase blood sugar and promote obesity. Limited information exists regarding the outcome of these compounds on the maternal metabolism and that of the offspring.Funding proposalsHow has a 'water only' and 'healthy kai' school policy impacted on child obesity
This study will assess the effect of a low sugar food and drink policy on a range of important child health and learning outcomes.Funding proposalsNaturally occurring peptaibols: “magic bullets” for targeting breast cancer
Amplification of human epidermal growth factor receptor 2 (HER2) occurs in 20% of breast cancers and confers an aggressive tumour phenotype with a poor prognosis. There is currently no cure for advanced HER2-positive breast cancer.Funding proposalsHavelock North campylobacter outbreak study
In August 2016, more than 5000 people became infected with Campylobacter in Havelock North as a result of water supply contamination.Funding proposalsLook before we leap: strategies for treating mild neonatal encephalopathy
Therapeutic hypothermia is routine care for babies with brain injury due to low oxygen at birth. In randomised clinical trials, it has been shown that hypothermia improves survival without disability in babies with moderate or severe brain injury.Funding proposalsA novel target for the control of arrhythmias
A major cause of cardiac dysfunction is the disruption of the coordinated calcium signalling pathways within the cells of the heart. A protein pivotal in regulating cardiac cell calcium signalling is RyR2.Funding proposalsMore gain, less pain from chemoradiation for rectal cancer by adding simvastatin
In this clinical research trial, we explore whether the cholesterol-lowering drug simvastatin can improve treatment given for cancer of the rectum.Funding proposalsDevelopment of a 3-D printed thoracoscopic oesophageal atresia simulator
This project will develop a model to be used by paediatric surgeons to practice and acquire the skills for a difficult and challenging keyhole (thoracoscopic) operation in babies (neonates).Funding proposalsSmart phone delivered CBT for gambling related harm: An RCT
Harms from gambling are a major public health problem in NZ. People with addictions, including problem gambling, respond to seeing ‘cues’ that make them feel strong urges to take part in the addictive behaviour.Funding proposalsThe home environment of Tongan children
Identifying and analysing the risk factors present in the homes of children in Ha'apai, Tonga, and addressing them to reduce the spread of infectious disease across the Pacific, particularly to New Zealand.Funding proposalsEmerging sources and pathways for leptospirosis - a paradigm shift
People contract leptospirosis through contact with animal urine and contaminated water.Funding proposalsMechanisms of neural network metaplasticity via astrocytes
The ability to learn and remember is fundamental to all mental processes. In the brain, learning occurs through changing the strength of transmission at the synaptic junctions between nerve cells.Funding proposalsCo-creating a digital self-help intervention for people with persistent pain
Persistent non-cancer pain affects more than one in five New Zealanders. Māori, people living in areas of high deprivation and older adults are at greatest risk.Funding proposalsEvaluation of a new screening tool for atrial fibrillation in Pacific people
Atrial fibrillation (AF) risk is increased in Pacific people and is associated strongly with stroke incidence, which also is increased in Pacific people.Funding proposalsWhānau consent: an expression of indigenous rights
Issues that affect Maori health need to be explored from a Maori worldview if they are to be effectively addressed. A rising area of importance to Maori health, and indigenous health worldwide, is the field of tissue, gene, and individual data collection.Funding proposalsA new combination therapy for cancer
The precision medicine concept advocates delivering targeted therapies selectively to those who will benefit most. Drugs targeting oncogenic mutations driving cancers have been a major focus of such strategies.Funding proposalsFractures and falls among older adults in New Zealand.
The study focuses on fractures and falls among older populations in New Zealand.Funding proposalsEffects of housing quality and stability on the health of Pacific children in New Zealand
The aim of this research is to explore the impacts of housing quality and stability on health outcomes of Pacific children in New Zealand, including Pacific ethnic-specific data (i.e.Funding proposalsSupporting Cook Islands communities to access scientific evidence
The Cook Islands Ministry of Health have identified the importance early-life nutrition in support of primary NCD risk reduction. This study will explore associations between early-life environmental exposures and indicators of NCD risk at adolescence.Funding proposalsThe foster caregiving relationship with new-borns who have feeding difficulties
The intention of this study is to expand on foster care research by looking at the caregiving relationship with new-borns who have difficulties feeding.Funding proposalsAcceptability of the treadmill six-minute walk test in Pacific peoples
The traditional hallway six-minute walk test has been used successfully as a measure of cardiorespiratory fitness in Maori and Pacific peoples with multi-morbidity.Funding proposalsBanishing tumour hypoxia to render cancer immunotherapy curative
Immunotherapy (checkpoint blockade) is a promising new treatment option for cancer that is curative in some cases.Funding proposalsHinemoana: Our Ocean Narratives
“Hinemoana: Our Ocean Narratives” will scope a research project that documents the narratives of Maori, Hawaiian and Rarotongan women who paddle waka ama/outrigger canoes and/or have engaged with voyaging va’a, and explore women’s engagement with waka/va’aFunding proposals