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Mechanisms and Management of Musculoskeletal Disease

36 months
Approved budget:
Professor Ian Reid
Health issue:
Proposal type:
Programme Extension
Lay summary
This programme addresses important issues in musculoskeletal health and biology in three themes. Relationships Between Fat and Bone: Adiposity is one of the most important determinants of skeletal strength, so a mechanistic understanding of this relationship will inform strategies to reduce osteoporosis Osteoporosis Studies: Our major study in osteoporosis management is a trial of 2000 women with osteopenia (moderately reduced bone density) who are randomised to infusions of the bisphosphonate, zoledronate, or placebo at 18-month intervals Bone Erosion in Gout: Bone erosion is a frequent manifestation of chronic tophaceous gout and leads to joint damage, pain and disability