2305 Results
Generating pulses with KNDy neurons
The brain controls the levels of hormones circulating in the blood. The fertility hormones are secreted in a pulsatile manner that is essential for normal reproduction in humans.Funding proposalsSupporting informed e-cigarette use: A mixed methods study
Although electronic cigarettes (ECs) could reduce the harm caused by smoking, they may also present risks. While smokers would benefit if they replaced smoked tobacco with ECs, many continue smoking and remain at risk of serious harm.Funding proposalsPhysiological pacing to improve cardiac output in heart failure
A third of people diagnosed with heart failure die within the first year. The survivors have severely impaired quality of life because even day to day menial activities leave them breathless and incapacitated.Funding proposalsEffect of early childhood ear infections on language, cognition and behaviour
The preschool years are when the foundations for subsequent development are laid. Otitis media is a prevalent early life health issue. Understanding its impact on children’s development is crucial.Funding proposalsBiodiscovery and biosynthesis of new drug candidates
Less than one percent of the earth’s microbial diversity has been successfully cultivated in a laboratory setting, however the antibiotics and other natural products produced by this small fraction have provided some of the most important medicines in clinFunding proposalsCreating safer workplaces: understanding our work related fatalities
In the aftermath of the catastrophic Pike River Mine explosion New Zealand's poor workplace health and safety record has been under scrutiny.Funding proposalsExploring the development and impact of changes in community pharmacy services
Since the introduction of the New Zealand Primary Health Care Strategy in 2001 there has been a growing emphasis on enhancing primary health care services in order to keep people well within the community and to address health inequalities.Funding proposalsCommunity water supplies: ensuring microbial safety for disease prevention
Each year, tens of thousands of New Zealanders succumb to gastroenteritis caused by protozoan, bacterial and viral contamination of drinking-water supplies. Current tools available for assessing microbial removal from water supplies are limited to E.Funding proposalsGenomic analysis of adverse drug reactions
Adverse drug reactions (ADRs) cause a great deal of illness and death, and limit therapeutic options. Some ADRs result from differences in individual genetic make-up, and it is likely that many others have genetic origins.Funding proposalsMe mutu kai paipa - improving the provision of cessation to NZ smokers
The Quit Line (Me Mutu) is the world's leading smoking cessation telephone line having supported over 500,000 quit attempts and over 100,000 successful quits since 2000.Funding proposalsEstablishing drainage of thoracic duct lymph for longitudinal clinical studies
Animal studies of acute disease show that lymph fluid draining from the gut causes inflammation and failure of vital end organs, such as the heart, lungs and kidneys.Funding proposalsStructure-directed discovery of next-generation antifungals
There is an urgent need to augment the widely-used and well-tolerated but drug resistance susceptible triazole antifungals with broad-spectrum drugs that target fungal lanosterol 14α-demethylase (CYP51) and not its human homologue or other cytochrome 450 eFunding proposalsTargeting toxic gut lymph to treat acute disease
Acute diseases (ADs) are a common and global concern which include sepsis, pancreatitis, bleeding and shock. People die from ADs by failure of vital organs. For this there is no specific treatment, only organ support in intensive care units.Funding proposalsReducing the burden of atrial fibrillation
Atrial fibrillation (AF) is an irregular heart rhythm that is common and is associated with impaired heart function, stroke and increased risk of hospitalisation or death.Funding proposalsSmoking relapse prevention in COPD patients
Smoking remains the leading cause of Chronic Obstructive Pulmonary Disease (COPD), a leading cause of death and disability in New Zealand. COPD particularly affects Māori and Pacific people, given their higher rates of smoking.Funding proposalsHonour project Aotearoa
This project will investigate understandings of well-being and access to health services for the Maori Takatapui community.Funding proposalsTranslational advances in faecal incontinence and anterior resection syndrome
This project aims to achieve fundamental progress in two deeply distressing diseases: faecal incontinence and anterior resection syndrome (bowel dysfunction after surgery).Funding proposalsTowards streetscapes promoting inclusive mobility, health and wellbeing for all
Can Auckland’s evolving streetscapes and ‘leading-edge’ transport designs enable older residents and people with disability to meaningfully participate in society and enjoy positive health?Funding proposalsThe next generation studies
The Next Generation Studies are two closely-related studies with the children of the long-running Dunedin Multidisciplinary Health and Development Study participants: the Parenting Study investigates how parenting practices are passed from one generation tFunding proposalsFructose and the heart: targeting novel mechanisms of diabetic cardiomyopathy
Diabetes is epidemic and has been linked with excess dietary intake of fructose. The diabetes prevalence and mortality rate in New Zealand is rising dramatically and is disproportionately high in Maori populations.Funding proposalsTargeting cancer vaccines to human dendritic cells via CD301
Immune therapy for cancer is one of the most exciting developments in medicine today. Recent clinical trials are showing many patients with very advanced cancer experiencing long-term remissions that are likely to be permanent.Funding proposalsCommunities fighting sugar in soft-drinks
To determine the effectiveness of a school and community based intervention that employs social marketing, gamification, peer leadership, education and a policy approach to reduce sugar sweetened beverage (SSB) intake and unhealthy weight gain in Maori andFunding proposalsImproving outcomes of patients with atrial fibrillation in primary care
Atrial fibrillation is a common irregularity of the heart rhythm which increases the risk of stroke.Funding proposalsProliferating tumour-associated macrophages in human cancers
Immune therapy is showing tremendous promise against cancer, with two new drugs causing long-lasting remissions from very advanced cancer in some patients.Funding proposalsMaori and bipolar disorder
While there is evidence for Māori having increased prevalence and worse outcomes with bipolar disorder, little is known about the factors contributing to these disparities or strategies to reduce them.Funding proposalsPotentiation of targeted cancer therapies by statins
Statins are drugs that are widely used to reduce circulating cholesterol levels to prevent heart disease. Epidemiological evidence also indicates they may have protective effects against some cancers.Funding proposalsWhat predicts regression from prediabetes to normal glucose regulation?
Prediabetes is a high-risk state for type 2 diabetes (T2DM) and cardiovascular disease. Regression to normoglycaemia significantly reduces risk, even if regression is transient. In NZ prevalence of diabetes is 7% and prevalence of diabetes is 26%.Funding proposalsHe oranga ngakau: Maori and trauma informed care
Within the Mental Health sector in Aotearoa there is an increased emphasis on Trauma Informed Care approaches.The current approach is informed primarily by western psychological definitions and a dominant view of what constitutes trauma that does not proviFunding proposalsWork-related risk factors for cardiovascular disease
Cardiovascular disease (CVD) is the leading cause of death in New Zealand (NZ). There is evidence that occupational risk factors play a role in CVD; however, there are many knowledge gaps in part due to the relative lack of research in this area.Funding proposalsTransfusion requirements in patients for cardiac surgery - TRiCS III
Cardiac surgical patients are one of the main users of blood products accounting for approximately half of all transfusions in surgical patients. Annually around 3500 cardiac operations are performed in New Zealand.Funding proposalsRepurposing amiloride derivatives as new agents for drug-resistant tuberculosis
Tuberculosis (TB) disease is increasing and drug-resistant M. tuberculosis strains are becoming more prevalent through the importation of these strains from high incidence countries (Asia-Pacific).Funding proposalsTargeting human atrial microstructure: The key to resolving atrial fibrillation
Atrial fibrillation (AF) leads to an irregular and rapid heart rate, and is the most common heart rhythm disturbance. One in five strokes in people aged over 60 years is caused by AF. AF contributes significantly to the national health burden.Funding proposals