2305 Results
Searching for novel antimicrobials
With Pacific island researchers, we have recently reported successful culturing of bioactive bacteria, including Streptomyces and rare Actinomycetes from a limestone cave in Fiji.Funding proposalsTransforming crisis communication for linguistic minority communities
This 18-month project aims to enable more inclusive, effective and interactive crisis communication to improve health outcomes for linguistic minority communities.Funding proposalsA revolutionary solution to a chronic healing problem
The rise of diabetes, greater longevity and increasing cost of health delivery, makes interventions to reduce patient time in the health care system a priority.Funding proposalsOur Flow: increasing access to health-screening through menstrual blood
Premenopausal females will menstruate ~9-12 times a year.Funding proposalsAvoiding detection: How does gonorrhoea survive within host cells?
Neisseria gonorrheoae is an extraordinary bacterium, that is finely tuned to its human host.Funding proposalsRapid identification of leads for antimicrobials
There is an urgent need for replacements for antibiotics. During evolution bacterial viruses have evolved to manipulate or destroy specific human pathogens.Funding proposalsDo shed a tear for me: novel biomarker methods for Parkinson’s disease
Parkinson’s disease is an incurable progressive neurological disorder that is projected to become increasingly common as our population ages.Funding proposalsDeveloping novel devices to relieve congestion in heart failure
The number one reason why patients over 65 years go to hospital is heart failure. Specifically, patients experience accumulation of fluid in the chest cavity which leads to signs and symptoms of congestion.Funding proposalsRobotics system for rapid deployment of teleophthalmology
Clinicians are making swift moves to compensate for the social distancing necessary to keep safe in the post-COVID-19 era.Funding proposalsWāhi Kōrero: "I felt too whakamā to go to the doctor…”
This research will examine barriers to healthcare to improve health service outcomes and reduce inequities.Wāhi Kōrero is our innovative online research platform, where we invite whānau to respond to story prompts.Funding proposalsCirculating tumour DNA in hastening the diagnosis of lung cancer
Lung cancer is New Zealand’s top cancer research priority as it is the leading cause of cancer-related death and disproportionately disadvantages Māori and Pacific people.Funding proposalsMaternal perception vs actual breast milk supply: is there a difference?
The first 1,000 days are the foundation for lifelong health and wellbeing. Although exclusive breastfeeding is recommended until around 6 months of age, relatively few mothers in New Zealand reach this milestone.Funding proposalsGenomics and functional metabolomics of phaeochromocytomas and paragangliomas
Phaeochromocytomas and paragangliomas (PCC/PGL) are closely related neuroendocrine tumours that produce catecholamines; adrenaline, noradrenaline and/or dopamine.Funding proposalsSleep, mental health and wellbeing for young people: An online RCT of apps
Sleep generally, and especially for young people, has not yet received adequate research attention. In NZ, 39% of young people sleep less than recommended for their age, with 57% reporting poor quality sleep.Funding proposalsUnravelling the role of protein oligomerisation in acute myeloid leukemia
Acute myeloid leukaemia (AML) is an aggressive cancer with a 25% survival rate. Approximately 700 adults and 40 children are diagnosed with AML in New Zealand each year. Our fundamental understanding of key mechanisms behind AML remains incomplete.Funding proposalsProlactin-mediated suppression of fever during pregnancy
The maternal brain undergoes numerous physiological adaptations that ultimately safeguard the healthy development of offspring.Funding proposalsBuilding a synthetic biology pipeline to develop nucleoside therapeutics
This project seeks to develop a synthetic biology platform that combines discovery and sustainable production of novel nucleoside analogues, to combat bacterial and viral infections.Funding proposalsThe adaptation of a web-based psychosocial intervention for cancer survivors
Nearly a quarter of haematological cancer survivors in New Zealand are significantly distressed in the post-treatment period; moreover, cancer survivors often report needing more psychosocial support.Funding proposalsThe relationship between physical activity and gout flares
Gout is a common form of inflammatory arthritis in Aotearoa, characterised by unpredictable flares of intense pain.Funding proposalsNovel targeted therapeutic strategy for ovarian cancer treatment
Ovarian cancer is the 5th leading cause of death in New Zealand women with a mortality rate of over 60% which is the highest among gynaecological cancers. Nearly all ovarian cancer patients face a traumatising and incurable phase.Funding proposalsThe effects of climate variability on the risk of enteric diseases
Enteric disease is a common seasonal illness which disproportionately affects Māori and Pasifika. Its risk is expected to rise with climate change, and we need evidence specific for Aotearoa New Zealand.Funding proposalsToward profiling and treating neurosteroid withdrawal in catamenial epilepsy
Epilepsy is one of the most common and debilitating neurological conditions in the world, affecting 1-2% of the population.Funding proposalsProtecting hapū māmā and pēpi from vaccine preventable diseases
Maternal immunisation against pertussis and influenza protects hapu māmā and pēpi from infection and potentially fatal outcomes. The safety and efficacy of these vaccines are well documented.Funding proposalsHarnessing the immune system for predicting adverse postoperative recovery
As the burden of surgery rises in Aotearoa NZ, so too will the incidence of postoperative morbidity and mortality.Funding proposalsAffirming cognitive behaviour therapy for Rainbow youth and whānau in Aotearoa
Rainbow youth in Aotearoa experience health-sectored defined mental health challenges (e.g., depression, anxiety, suicidality) at a higher rate than their cisgender, heterosexual peers, and more than half report negative, invalidating experiences with mentFunding proposalsPrevalence of refractive error and access to eye care for New Zealand children
Uncorrected vision conditions in childhood have been linked to poorer early literacy, reduced self-esteem, increased rates of being bullied, and disengagement with education.Funding proposalsCan assisted reproductive technologies better assist Pacific people in Āotearoa?
Pacific peoples access assisted reproductive technologies (ART) at lower rates than other ethnicities in Āotearoa, NZ, despite experiencing higher levels of infertility.Funding proposalsThe therapeutic potential of kava in the treatment of psychological trauma
The incidence of post-traumatic stress disorder (PTSD) and trauma-related distress (subsyndromal PTSD) is increasing.Funding proposalsCan loss of a ‘hunger’ hormone increase cardiovascular disease in Pacific people
In New Zealand, Pacific Island peoples (PI) are disproportionally over-represented in those with diabetes and cardiovascular disease (CVD). The reasons for this disparity remain unclear.Funding proposalsTIPS: Trans-Tasman Internet-delivered Prevention of (youth) Suicide
Rates of youth suicide are alarming. A key predictor is suicidal ideation (i.e., thoughts about, or plans of, ending one’s life) with rates up to 20% every year. Suicide and suicidal ideation disproportionately affect rangatahi Māori.Funding proposalsA compositional neurophysiological biomarker for predicting stroke recovery
Stroke is a leading cause of adult disability. Recovering hand and arm function is critical to regaining independence. We developed the PREP2 tool to evaluate how well a patient’s hand and arm is likely to function 3 months after stroke.Funding proposalsPDE9: inhibition in experimental MI and plasma levels in human heart disease
Heart disease remains a leading cause of death and disability in New Zealand. Myocardial infarction, commonly known as a heart attack, is a key cause of progressive heart disease.Funding proposals