Lay summary
Stroke is a leading cause of adult disability. Recovering hand and arm function is critical to regaining independence. We developed the PREP2 tool to evaluate how well a patient’s hand and arm is likely to function 3 months after stroke. This prediction can be made within the first week post-stroke and improves patient and therapist experiences and rehabilitation efficiency. PREP2 combines clinical and neurophysiological assessments to predict one of four outcome categories for each patient, with 75% overall accuracy. The tool is now used in routine clinical care in hospitals in the North Island and is under evaluation at several international sites. The aim of this project is to improve the overall accuracy of the tool. We will achieve this aim by developing and testing a novel compositional neurophysiological biomarker with patients in a real-world clinical setting as a first step toward the development of PREP3.