2305 Results
Omega-3 fats during obese pregnancy, for metabolic protection of the offspring
This project aims to protect the metabolic health of children born to women who are obese during pregnancy, using an unoxidised fish oil supplement.Funding proposalsUsing Chinese medicine to treat tinnitus: targeting metabolic networks
Chronic tinnitus is a debilitating condition that significantly reduces quality of life and presents a considerable socioeconomic impact to society.Funding proposalsPathogenesis, detection and treatment of perinatal brain injury
Perinatal brain injury affects over a million babies around the world, and can lead to severe, lifelong disability. The key causes are low oxygen at birth and infection/inflammation.Funding proposalsBiomechanics in heart disease
Cardiovascular disease is the largest cause of death worldwide. Effective diagnosis and treatment are hampered by a lack of knowledge of the pathophysiological mechanisms underlying the development of disease.Funding proposalsReducing the burden of gastric cancer in New Zealand
Gastric (stomach) cancer is the 2nd greatest cause of cancer death worldwide. In New Zealand, it is remarkable for its incidence in Maori and Pacific people being three fold greater than in non-Maori.Funding proposalsInterventions to Reduce Occupational Disease (iROD)
Occupational disease is largely preventable through the reduction of causal exposures.Funding proposalsPrevention of asthma
Asthma rates in New Zealand are amongst the highest in the world. Previous research has suggested that paracetamol given in the first year of life may be responsible for up to 22% of later asthma.Funding proposalsReal time in situ antibiotic sensitivity testing
We are proposing to completely change how bacterial resistance is detected – saving patient lives and healthcare resources.Funding proposalsA proton switch for T cell migration and activation
In this proposal, we will exploit the low pH environment of solid tumours to enhance T cell immunotherapy.Funding proposalsTransforming women's pelvic floor health.
Urinary incontinence and pelvic organ prolapse, affect one in four women. Weak pelvic floor muscles are usually part of the problem.Funding proposalsTowards bone regeneration by developing electroactive hybrid materials
Population aging is a worldwide phenomenon and the number of people in need of total joint replacement surgery is growing steadily.Funding proposalsAn international collaboration to reduce infant obesity in high risk groups
New Zealand (NZ) and the United States (US) are experiencing an epidemic of obesity in early childhood, with 25-30% of preschool-aged children being overweight or obese.Funding proposalsLinking viruses that call uterus home and unexplained female infertility
Infertility is a common problem affecting 1 in 6 couples in NZ today. For many of infertile couples, IVF represents their best chance of having children.Funding proposalsIndigenous approaches to reducing childhood obesity
Obesity is a systemic problem which demands systemic solutions. Indigenous populations in NZ and the US suffer from a high prevalence childhood obesity.Funding proposalsTechnology-enabled behaviour change to reduce childhood obesity
This proposal is to establish a US-NZ research collaborative to design, develop and evaluate a family-based technology-supported childhood obesity prevention programme, particularly for indigenous and priority population groups in NZ, US, and countries/terFunding proposalsPrevention of childhood obesity through sugar reduction
The purpose of this proposal is to fund the collaboration efforts of researchers from two New Zealand Universities (The University of Auckland and University of Otago) to collaborate with a research team from the University of Colorado (USA) led by ProfessFunding proposalsDeveloping the holy grail of bioprinting: vascularisation
The effective treatment of acute, deep tissue and/or nonhealing wounds (e.g. pressure ulcers) poses a massive challenge to clinicians around the world. Researchers are looking to three-dimensional bioprinting of human skin for the solution.Funding proposalsMaternal bacteria to correct abnormal gut microbiota in babies born by C-section
C-section may cause acute complications, but there are also adverse long-term health effects, such as increased risk of obesity and immune disorders in the offspring.Funding proposalsChanging our view of tobacco dependence: the monoamine oxidase inhibitor story
Nicotine does not act alone in causing tobacco dependence and with monoamine oxidase inhibitors the most likely culprit, we took a closer look at the inhibitors in tobacco smoke. We discovered a monoamine oxidase inhibitor unlike any previously reported.Funding proposalsDeveloping an innovative performance measurement framework for health care
An outcome-driven Performance Measurement (PM) framework is currently mandated by the Ministry of Health to monitor the performance of public hospitals. This measures DHB performance against national targets.Funding proposalsTransforming nutrition and food security in New Zealand: enabling communities
Poverty is directly related to the poor and unreliable access to nutritious food.Funding proposals‘No drill, no fill’ – a novel substitute to regrow teeth
Dental caries remains a major public health concern in New Zealand, as well as worldwide, and the management of this disease requires large sums of public health funding and resources.Funding proposalsTargeting growth hormone signal transduction in breast cancer
One of the most successful strategies for treating breast cancer has been the use of humanised monoclonal antibodies to target secreted growth factors or cell surface receptors whose function has been upregulated in the tumour.Funding proposalsDevelopment of inhibitors of PC-PLC as anticancer therapeutics
Many patients with metastatic breast cancer do not respond to conventional chemotherapy and better strategies to treat these patients are urgently needed.Funding proposalsThe potential of immunotherapy as a treatment for ER+ve breast cancer
Treatments that stimulate the immune system to attack tumours have revolutionised the treatment of some cancer types. However, these treatments have not yet been used effectively in breast cancer.Funding proposalsGenetic and molecular basis of drug resistance and drug action in vivax malaria
Plasmodium vivax infects ~20 million people each year. Most of these vivax malaria cases occur in the Asia-Pacific region where more than 2 billion people are at risk of infection.Funding proposalsAhi Kā and expressions of manaakitanga
The proposed research builds on results from a previous NKK grant where we found strong association between expressions of ahi ka and hauora.Funding proposalsYoung Maori women & LARCs: ensuring good access whilst guarding against coercion
This project identifies and examines health system barriers that young Māori women in the Counties Manukau region experience when they seek to access Long Acting Reversible Contraceptives (LARCs).Funding proposalsTaurite Tu: development of falls prevention exercise programme for Maori.
Research Objectives: 1)To establish Ropu Kaiawhina to guide and inform full research project; 2) To develop and consolidate relationships between Te Runanga Otakou and other independent, reputable experts to best address falls related health issues for TeFunding proposalsPrimary care e-screening for mental health among TeTai Tokerau youth
YouthCHAT is an electronic screening tool developed in 2016 to assess risk taking behaviour and detect mental health concerns among youth in primary care settings.Funding proposalsPathways to first episode psychosis and outcomes in Maori
There is some evidence for Maori having increased prevalence and worse outcomes following diagnosis a psychotic disorder. However, little is known about the factors contributing to these inequities or strategies to reduce them.Funding proposalsIndigenous solutions: enabling Maori & Pacific mental health resilience
Previous research with Pacific and Maori in the mental health domain has valued cultural conceptualisations of health and wellbeing.Funding proposals