2360 Results
Transforming diagnostic pathways for Alzheimer’s disease using blood biomarkers
Blood biomarkers of Alzheimer’s pathology offer a transformative tool for diagnosis and prognosis of New Zealand's most common cause of dementia mate wareware (dementia).Funding proposalsA new generation of weight loss medication
Weight loss drugs targeting GLP1 receptors (e.g.Wegovy/Ozempic) provide compelling evidence medical treatments for obesity and are highly effective. However, these suppress appetite which can reduce social interaction and enjoyment of life.Funding proposalsDeveloping an epigenetic score to identify people at impending risk of a heart attack
Current screening tools for cardiovascular risk fail to identify many high-risk individuals, with more than 50% of heart disease deaths occurring in people assessed by their GP to be low-moderate risk.Funding proposalsCommunity-based crosslinking treatment in keratoconus
Keratoconus (KC) causes significant visual impairment and disproportionately affects Māori and Pacific peoples. Corneal crosslinking (CXL) is a minor procedure and an effective treatment for KC.Funding proposalsTargeted antioxidant delivery strategies to prevent lens cataract
With an aging population, cataracts are becoming increasingly common, driving up demand for cataract surgery and placing significant pressure on hospital systems, leading to long waiting times.Funding proposalsMusic and movement for mild cognitive impairment: the RGM trial
The ageing demographic means prevention of dementia is an international and national priority. People with mild cognitive impairment (MCI), an early (prodromal) stage of dementia, are also at high risk of falls.Funding proposalsShifting focus: Risk-framed messaging and visualisation for childhood vaccines
Current health promotion focuses on reassuring families that vaccines are “safe and effective,” a framing that works when trust is high. In the current climate of misinformation and declining vaccine confidence, many parents now see vaccines as risky.Funding proposalsHerpes zoster and neuroinflammation: a modifiable pathway to dementia
Dementia is one of the most pressing health challenges facing New Zealand, particularly for Māori and Pacific peoples who experience higher rates and earlier onset. Current treatments are limited, and prevention strategies are urgently needed.Funding proposalsTransforming hydrocephalus care with home brain pressure monitoring
Hydrocephalus involves fluid buildup around the brain, requiring a surgically implanted tube for drainage. Patients and caregivers worry about tube blockages, with nonspecific symptoms like irritability, headaches, and vomiting.Funding proposalsCo-creating a mental health care pathway for the New Zealand's nursing workforce
The New Zealand nursing workforce faces ongoing challenges related to mental health, including elevated risks of anxiety, depression, burnout, and suicide.Funding proposalsEnhancing mitochondrial metabolism to optimise CAR T-cell therapies
CAR T-cell therapies are a revolutionary type of cancer treatment that work by training a patient’s immune system, specifically T cells, to hunt and kill cancer cells.Funding proposalsEmbedding disabled people’s expertise in health design
Disabled people possess valuable expertise in maintaining their health and wellbeing.Funding proposalsCo-designing better health service delivery to tackle opioid overdoses
Fatal accidental opioid overdoses are increasing in New Zealand, up 32% in recent years.Funding proposalsTrapping antibiotics inside pathogens to accelerate infectious disease therapy
Disease causing (pathogenic) mycobacteria are the causative agents of some of humankind’s greatest afflictions, including tuberculosis (TB), leprosy, and Buruli ulcers.Funding proposalsPae Herenga - Informing service development of paediatric palliative care
This study will collect the first comprehensive New Zealand data of whānau and family experiences of paediatric palliative care for both Māori and non-Māori.Funding proposalsTackling early-onset colorectal cancer in Aotearoa
Rates of bowel cancer in younger adults under 50 are rising rapidly in Aotearoa New Zealand and overseas.Funding proposalsProphylactic antibiotics to reduce mortality in ICU patients with brain injuries
Severe brain injuries from accidents, strokes, cardiac arrests, or bleeding in the brain are a leading cause of death and long-term disability in New Zealand.Funding proposalsTimely detection and treatment: Closing the breast cancer gap for Pacific women
Breast cancer is the most common cancer affecting Pacific women in Aotearoa New Zealand, yet survival outcomes are far worse compared with other women. Pacific women are often diagnosed younger, at later stages, and face greater delays in treatment.Funding proposalsWhat matters most in palliative care for Pacific families and in what context?
This study focuses on improving palliative care for Pacific peoples in Aotearoa New Zealand.Funding proposalsŪloa in action: Implementing and evaluating a Pacific service model
This project will co-design, implement, and evaluate a Pacific community mental health care pathway at Te Whatu Ora Counties Manukau, based on the Ūloa model; a culturally grounded framework for coordinated, collaborative, and holistic care.Funding proposalsCo-designing with Pasifika families to improve diabetes in pregnancy management
Pasifika women in Aotearoa experience disproportionately high rates of diabetes in pregnancy (DiP), contributing to poor outcomes including elevated perinatal mortality.Funding proposalsBuilding a Pacific CVD biorepository for biomarker discovery and risk prediction
Cardiovascular disease (CVD) is the leading cause of premature mortality among Pacific peoples in Aotearoa New Zealand compared with the general population.Funding proposalsMyocardial marker enhanced data to improve cardiovascular care in New Zealand
Our proposal - Myocardial Marker Enhanced Data to Improve Cardiovascular Care in New Zealand (MEDICi-NZ) aims to make widely collected cardiac blood tests fully useful in improving care for New Zealanders at risk of adverse heart events.Funding proposalsMachine learning to personalise oxygen therapy in the intensive care unit
Clinical trials usually tell us whether a treatment works “on average,” but they cannot show how each individual patient might respond. This is a problem because treatments that help some people can harm others.Funding proposals