Lay summary
Huntington’s disease (HD) is a progressive brain disorder caused by the loss of medium spiny neurons (MSNs), which are vital for movement and coordination. One promising treatment is cell replacement therapy, which aims to replace the lost brain cells. However, it’s currently limited by a shortage of suitable cells and poor survival of transplanted cells. This project will combine cutting-edge 3D bio-fabrication techniques with lab-grown human striatal neural precursors (hiSNPs) - immature brain cells that can develop into MSNs. By transplanting these hiSNPs within a protective hydrogel, we aim to improve cell survival, support their development into functional MSNs, and help them integrate into the brain. Testing this approach in a rodent model of HD could lead to restored movement and cognitive abilities. This research could pave the way for more effective cell-based treatments for HD in the future.