2305 Results
Urban farm-like dust: microbial origin and protective effects on later asthma
New Zealand has high rates of asthma and hospitalisations for asthma.Funding proposalsBlood-based biomarkers of dementia in a longitudinal birth cohort
Finding out if you have the early signs of Alzheimer’s disease from a simple blood test is getting closer to reality.Funding proposalsTowards tuberculosis elimination for Māori
This project concerns elimination of tuberculosis (TB), which causes a million deaths per year globally. Amongst NZ born TB cases, 49% are Māori, with a rate over five times that of NZ Europeans.Funding proposalsDigital technologies for stroke prevention: a randomised controlled trial
Stroke is the one of the top causes of death and disability worldwide. Patients with stroke and transient ischaemic attack (TIA) are at increased risk of recurrent (more disabling) stroke.Funding proposalsProtecting hapū māmā and pēpi from vaccine preventable diseases
Immunisation against pertussis, influenza, and COVID-19 during pregnancy is the only effective way to protect hapu māmā and their pēpi from these potentially fatal diseases.Funding proposalsWhere are the inequities in the journey from health to gynae cancer in Aotearoa?
Compared with non-Māori, Māori and Pasifika wāhine have a higher incidence and mortality from gynaecological cancer in Aotearoa NZ.Funding proposalsCancer targeted bioorthogonal prodrugs
Drugs used to treat cancer need to be targeted to tumours, otherwise the therapy might fail and the patient will experience side effects.Funding proposalsImproving lives of hydrocephalus patients - first human trial of a novel device
Patients with hydrocephalus have an abnormal build-up of fluid around the brain and need a tube surgically implanted to drain that fluid. Patients and their caregivers live with the constant fear that the tube will block.Funding proposalsStepped rehabilitation for people with persistent shoulder pain
A shift from passive to active self-management of musculoskeletal disorders has been called for, including shoulder pain, one of the most common types of musculoskeletal pain.Funding proposalsEstablishment of a new molecular target for arrhythmias and heart failure
A heart attack, otherwise known as a myocardial infarction, is the second leading cause of death in NZ. Those who survive suffer from arrhythmias and heart failure. Unfortunately, there are limited treatment options available for these patients.Funding proposalsTranslating, modelling and evaluating cannabis policy reform
Cannabis use in Aotearoa/NZ is currently responsible for $911 million of harm per year including convictions, youth use, and mental illness.Funding proposalsHinapōuri ki Hīnātore: Improving mental health outcomes and services
In New Zealand, specialist mental health and addiction service users (SMHAS-users) experience reduced life expectancy and greater morbidity than the general population. Māori SMHAS-users experience disproportionate health inequities.Funding proposalsToward a mechanism for CREBRF R457Q to drive diabetes protection
The CREBRF variant (R457Q) specific to Māori and Pacific populations has the largest effect size of any single genetic variant on body mass index (BMI) and yet despite higher BMI it is associated with a 50% reduction in diabetes.Funding proposalsA Randomised Controlled Trial of Oral Dexamethasone to treat Sydenham's Chorea
Sydenham’s chorea is a disabling disorder of uncontrollable movements and psychiatric symptoms which is seen in 6-28% of children with rheumatic fever.Funding proposalsIdentifying epigenetic markers for early detection of colorectal cancer
Colorectal cancer (CRC) death rates are particularly high in Aotearoa New Zealand and are increasing in younger people (age <50 years) and Māori, who are more likely to present with advanced stage of disease.Funding proposalsRelaxed quality control: how rogue AS-NMD drives cancer evolution
Cancer cells are continuously evolving under selective pressure by increasing their protein repertoire.Funding proposalsDisposable, not dispensable: reducing the incidence of cataract post vitrectomy
With an aging population, age related diseases of the eye are increasingly common resulting in the need for surgery. Vitrectomy is a common procedure in which the vitreous humor is removed to allow access to diseased retina and replaced with saline.Funding proposalsIdentifying central therapeutic targets in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a prevalent and poorly understood disorder, characterised by high circulating levels of 'male-typical' androgen hormones and infertility.Funding proposalsCurbing the reproductive hormonal axis to control PCOS
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility. Although some treatments for symptoms exist, there is currently no cure and infertility remains an intractable problem for many PCOS sufferers.Funding proposalsA molecular triage test to reduce colposcopy referrals after HPV testing
In 2023, the primary test for cervical screening will change to human papillomavirus (HPV) testing. HPV testing can be carried out on a self-collected swab, improving accessibility of screening for Māori and other women.Funding proposalsUnderstanding inequitable tuberculosis transmission in Aotearoa
In Aotearoa New Zealand (NZ), tuberculosis (TB) disproportionally affects Māori and Pasifika particularly children under 5 and 5-14 years, suggesting ongoing transmission is occurring in these communities.Funding proposalsTargeting microbial energetics to achieve a rapid cure for tuberculosis
Tuberculosis remains a leading cause of death from infectious diseases worldwide and the spread of drug-resistant tuberculosis threatens to return us to the pre-antibiotic era for this disease.Funding proposalsPlasticity of the skin IL-13+ innate lymphoid cell niche
We recently discovered that the healthy skin of humans and mice harbours a population of innate lymphoid cells that constitutively produce the cytokine IL-13.Funding proposalsA role for p53 isoform Δ133p53 in the progression of inflammatory bowel disease
Inflammatory bowel disease (IBD) is a life-long condition that has significant health and economic impact worldwide including in New Zealand.Funding proposalsThe New Zealand Quit Vaping Trial
Two policies in the Smokefree Aotearoa 2025 Action Plan involve decreasing the number of tobacco retailers and only allowing reduced nicotine tobacco to be sold.Funding proposalsBringing manaakitanga to waitlists with tailored Smart Start letters
When referrals are accepted by outpatient specialist health services, patients are often posted a letter offering an appointment some months away.Funding proposalsTargeting the tumour microenvironment to improve outcomes in rectal cancer
The incidence of rectal cancer is increasing in NZ, particularly in younger people (< 50 years).Funding proposalsLow OxyGen Intervention for Cardiac Arrest Injury Limitation (LOGICAL) Trial
This randomised clinical trial will test the hypothesis that using a conservative oxygen therapy regimen instead of a standard liberal oxygen therapy regimen reduces brain damage and improves survival with a good recovery in adults who are in a coma followFunding proposalsIMPEDE-PKD: Metformin to protect kidney function in polycystic kidney disease
IMPEDE-PKD is a clinical trial evaluating whether metformin prevents kidney failure in people with polycystic kidney disease (PKD). PKD is a genetic condition causing large kidney cysts.Funding proposalsConnected: Who benefits from online delivery of mental disorder treatment?
Early treatment of mental disorders is essential to reduce suffering and to decrease early mortality. Most prevalent among rangatahi aged 16-24, untreated mental disorder affects relationships, education, and career options.Funding proposalsProtecting the lungs of the critical illness patient
Key to managing many patients with significant illness is the preservation of sufficient oxygen delivery. When patients are very unwell this process can become compromised and mechanical ventilation is required.Funding proposalsFighting leukaemia colonisation of the haematopoietic niche
Acute myeloid leukaemia (AML) has a low survival rate of 22% in NZ. Treatment options for AML are limited and new strategies are needed to combat this disease.Funding proposals