2305 Results
Identifying biomarkers of aneuploidy in embryos
Aneuploidy, defined as variation from expected chromosome numbers, causes embryo failures following in vitro fertilisation (IVF). The world-wide trend of delaying childbirth increases maternal age and incidence of aneuploid embryos.Funding proposalsStaphylococcus aureus network adaptive platform trial (SNAP)
New Zealand has one of the highest rates of Staphylococcus aureus bacteraemia (SAB - bloodstream infection) in the world. Māori and Pacific people are particularly affected. The mortality of SAB is 15-20%.Funding proposalsResponding to Pacific maternal mental health
Antenatal and postnatal depression symptoms during the perinatal period is associated with negative impacts on maternal health, pregnancy outcomes, child health and child development.Funding proposalsPositive youth development in Māori youth through an adventure education program
The focus of the current study is the youth that take part in the 7-day youth development voyages run on the R. Tucker Thompson, a traditional gaff-rigged schooner based in the Bay of Islands, Northland, Aotearoa New Zealand.Funding proposalsErythropoietin to improve outcomes for critically ill trauma patients
Severe injury activates multiple chemical pathways causing inflammation and harming vital organs, which can lead to long-term disability and death. The kidney hormone erythropoietin controls red blood cell production and is a common treatment for anemia, bFunding proposalsRole of ryanodine receptors in Alzheimer’s disease
Alzheimer’s disease (AD) affects ~10% of people aged 65 and older, positioning it as a major concern for New Zealand’s aging population.Funding proposalsUnderstanding the role of IgG3 in acute rheumatic fever
Rheumatic fever (RF) is one of New Zealand’s starkest examples of health inequity, with Māori and Pacific children 20-40 times more likely than all other New Zealand children to develop the disease.Funding proposalsNgā Kaumātua ō Tātou Taonga: Supporting kaumātua health in a changing world
Over coming decades the number of Māori kaumātua will increase significantly across Tai Tokerau and the Waikato regions. This is reason for celebration.Funding proposalsMāori experiences with oral health services in Aotearoa
In Aotearoa, clear oral health disparities exist with Māori experiencing a high proportion of oral disease, predominantly manifesting as dental decay, when compared to non-Māori.Funding proposalsRCT budesonide-formoterol vs salbutamol reliever therapy in childhood asthma
Childhood asthma is a major public health problem in New Zealand. The evidence base for the treatment of childhood asthma is considerably less than for adult asthma.Funding proposalsUse of online technology for effective wellness and exercise programme delivery
An examination of all the potential media devices that could be used to deliver exercise and wellness programmes. Literature published after 2005 that have a focus on Physiotherapy, Māori Health and computer science will be researched.Funding proposalsHe Toa Taumata Rau - the many resting places of courage
The aim of this research is to investigate, determine, highlight and better understand the homecoming experiences and reintegration needs of returning New Zealand Defence force veterans and their whanau.Funding proposalsGalvanic vestibular stimulation as a treatment for neurological disorders
Galvanic vestibular stimulation (GVS) is a method of non-invasive electrical stimulation of the peripheral vestibular system (the balance system in the inner ear) that is used to test vestibular reflexes.Funding proposalsWellbeing and the precariat: How does it work in everyday life?
Work, income and wellbeing are closely related, with low income families generally experiencing poorer health outcomes.Funding proposalsBarriers and facilitators to self-management of asthma in Pacific children
Asthma prevalence in New Zealand is among the highest in the world with one in nine adults and one in seven children affected, with a disproportionately high and persistent burden among Pacific populations and Māori.Funding proposalsLifestyle program for Pacific
Pacific people in New Zealand have the highest rates of diabetes and cardiovascular disease (CVD) that increases their risk of CVD mortality compared to other New Zealand populations.Funding proposalsMāori women and methamphetamine addiction in pregnancy: A literature review
A kaupapa Maori literature review to identify some of the barriers to Maori accessing addiction and/or reproductive health services: the challenges Maori whanau face in our communities related to methamphetamine; and any potential enablers to Maori healthFunding proposalsCircadian patterns of fetal heart rate predict impaired fetal oxygenation
Poor growth before birth is associated with a high risk of death and brain injury. There are many causes of poor growth, and current clinical monitoring has a limited ability to identify babies who will need intervention.Funding proposalsEnabling clinical development of a novel hypoxia-targeted anti-cancer agent
The presence of low-oxygen zones (hypoxia) is a hallmark of many tumours, which confers negative prognosis and poor treatment outcomes after surgery, chemotherapy, and radiotherapy.Funding proposalsBarriers and cultural values for Pacific women accessing breast cancer care
What persistent barriers and cultural values need to be addressed for Pacific women when accessing breast cancer across the cancer care continuum?Funding proposalsRevitilisation of the Samoan traditional diet
High intake of sugars increases the risk of developing obesity and type-2 diabetes, with Maori and Pasifika most likely at risk.Funding proposalsCombating antimicrobial resistance with high-throughput bacterial genetics
Antimicrobial resistance is a major international public health crisis. Central to this problem are drug-resistant strains of Mycobacterium tuberculosis, the causative agent of tuberculosis.Funding proposalsA neural circuit required for maternal adaptation to pregnancy
Maternal care is critical to the survival of dependent offspring. We have recently described a prolactin-sensitive neural circuit centred in the medial preoptic area (MPOA) of the hypothalamus that is essential for a mother to look after her offspring.Funding proposalsThe roles of respiration and ATP production in tumorigenesis and metastasis
The ability of cancer cells to alter the balance between mitochondrial and glycolytic ATP production allows them to survive and metastasize under adverse conditions.Funding proposalsSmart delivery of growth factors for treating osteonecrosis of the femoral head
Avascular necrosis (AVN), also known as osteonecrosis, is a condition when there is a severe disruption in blood flow to the bone, leading to bone death.Funding proposalsReducing organ failure in critical illness
Severe acute disease and their associated critical illness states are the commonest causes for Intensive Care Unit (ICU) admission.Funding proposalsImproving nutrition delivery
Nutrition is a key component of health. When we are unable to obtain sufficient nutrition we sometimes need to be fed directly by tubes that carry liquid food directly into our gut.Funding proposalsBrain biomarkers for future cognitive health in Parkinson's disease
Parkinson’s disease (PD) is more than a motor disorder. Most patients develop cognitive impairments; this decline often progresses to dementia. There are no reliable predictors for future cognitive health in individual PD patients.Funding proposalsExploiting oxidative stress in the treatment of metastatic melanoma
Malignant melanoma is a deadly form of skin cancer that requires new therapies. Using a sensitive new technique we observed that melanoma cells have higher levels of oxidative stress than other cancer cells.Funding proposalsHe Tapu Te Whare Tangata: Empowering rural solutions
Whānau living in rural Aotearoa have barriers to timely care involving distance from centres, lack of community control and prioritisation of rural needs by District Health Boards.Funding proposalsTe Ao Rauropi: Mapping the biosphere of Rongoā Māori
Rongoā Maori is a holistic system of healing derived from Māori philosophy. Despite attempts in the 1900s to prohibit Rongoā, it has endured, albeit in a more limited form.Funding proposalsRandomised trial of a novel chyme reinfusion device for temporary ileostomies
New Zealand has the world's highest rates of colorectal cancer, and it is our second leading cause of cancer death. The formation of a "temporary ileostomy" is a cornerstone of colorectal cancer care, particularly for rectal cancer.Funding proposals