2305 Results
Rebalancing fluid distribution in critical illness
Acute critical illness is often associated with the development of oedema (tissue swelling). The basis for this relates to an imbalance between blood-derived fluid delivery to the tissues and its subsequent clearance by capillaries and lymphatics.Funding proposalsEnabling New Zealand biomedical research with superior targeted cell ablation models
Numerous research teams around New Zealand employ targeted cellular ablation models to study physiology and degenerative disease. Many of these models are flawed, exhibiting confounding off-target toxicities, insufficient killing of target cells, or both.Funding proposalsDevelopment of a non-invasive diagnostic test for endometriosis
Endometriosis is a chronic and debilitating condition and the most common cause of morbidity and infertility in women. It is characterised by the presence and growth of endometrium (womb lining) outside the womb.Funding proposalsInvestigating iNKT Cell-Based Vaccinology to Treat Drug Addiction
Drug addiction imposes an enormous burden on health, welfare and law enforcement both in New Zealand and worldwide. The social cost of drug-related harm in New Zealand is estimated at $1.8b annually.Funding proposalsTransforming the paradigm of functional genome organisation
Within the nucleus, genomic DNA is exquisitely packaged with proteins creating highly folded yet dynamic fibers of chromatin.Funding proposalsAsthma - a test case for precision
How mutations associated with asthma impact on the genes that are switched on and co-morbidity with other disorders (e.g. type 1 diabetes) is gradually being understood.Funding proposalsA novel device for early cancer detection
Cancer survival would be transformed if it could be routinely detected at an early stage. This is currently not possible for most cancers due to the absence of markers with sufficient sensitivity and specificity.Funding proposalsSynthetic Stem Cells – a New Area for Myocardial Infarction Treatment
Cardiovascular disease (CVD) and its complications, including myocardial infarction (MI), are associated with a level of mortality and morbidity that constitute a major healthcare issue and burden in New Zealand.Funding proposalsIdentification and monitoring of lymphoedema
The importance of the diagnosis of lymphoedema results from the frequent appearance of this problem, particularly after breast cancer treatment.Funding proposalsInterpretation of anomalous experiences: Implications for wāhine Māori
Wāhine Māori are disproportionately represented in negative mental health statistics. Culturally derived conceptualisations of mental health and illness should be considered in light of this.Funding proposalsUnderstanding dyspnoea and exercise limitation in interstitial lung disease
Interstitial lung diseases (ILD) are a group of conditions that cause lung scarring. Breathlessness during exercise is almost universal in ILD patients, yet we have limited treatment options available.Funding proposalsHealth and the Ta'unga: Cook Island palliative health knowledge in New Zealand
The aim of the proposed study is to explore the beliefs and understanding of palliative care of Cook Island peoples in New Zealand, from an indigenous Cook Island perspective.Funding proposalsNovel strategies to harness therapeutic potential of CB2 in the immune system
Our immune systems defend against disease. However, over-activity or mis-targeting of the system can be devastatingly harmful – as exemplified in autoimmunity, neurodegeneration and atherosclerosis.Funding proposalsDeveloping Tongan-centred ways to improve primary health care access in Auckland, New Zealand
Quality of health care is a crucial part of the Pacific journey when accessing primary health services. However, many are less likely to be satisfied with their general practitioner and pharmacies are not perceived to resolve medication problems.Funding proposalsVulnerability of the female heart
The aim of the project is to answer the question: “Why is it that the female heart is more affected by cardiovascular disease than is that of the male?” The hypothesis that the female heart is more vulnerable because of the lowered ability of heart muscleFunding proposalsImproving Pacific youth wellbeing: co-creation and evaluation of a digital tool
The aim of this research is the improving the mental wellbeing of Pacific youth through co-creation and evaluation of a digital tool.Funding proposalsImplementing effective treatments: Parent training for cUonduct problems
Internationally, conduct problems are one of the most common reasons children and families seek help from mental health services.Funding proposalsAdult stem cell treatments for corneal endothelial diseases
Corneal endothelial dysfunction results in loss of vision, for which corneal transplantation is the definitive treatment. Due to limited supply of donor tissue, alternatives are required.Funding proposalsPrecision cancer treatment using predictive software and imaging biomarkers
Precision medicine is a rapidly growing field in oncology which aims to provide the best treatment by tailoring it to an individual patient’s cancer.Funding proposalsDoes a sleep intervention reduce weight gain in infancy? A novel approach
Improving sleep in infants has been shown to substantially reduce the risk of child obesity, but in predominantly European populations.Funding proposalsMindfulness based cognitive therapy for family carers of people with dementia
New Zealand has a fast growing ageing and dementia population. Family carers of people with dementia have little support and intervention despite high levels of distress associated with their role.Funding proposalsEstimating the cost of dementia care in NZ and modelling future costs and needs
As the proportion of the NZ population aged 65 years and older increases, there will be a concomitant increase in dementia cases, projected to triple by the year 2050 and resulting in increased strain on the health system.Funding proposalsEvaluating a model of care for patients with chronic obstructive pulmonary disease (COPD) in their last year of life
Only 2 – 9% of patients with chronic obstructive pulmonary disease (COPD) ever receive the benefit of specialist palliative care.Funding proposalsTowards a new Penicillin for Rheumatic Fever prevention
Acute Rheumatic Fever (ARF) is an autoimmune condition caused by untreated group A streptococcal (GAS) infection of the throat and possibly skin. Multiple or severe attacks of ARF can cause permanent heart damage known as rheumatic heart disease (RHD).Funding proposalsImproving outcomes for children and adolescents with diabetes
Diabetes is a common chronic disease of childhood in NZ: each year there are >200 new cases of whom 25% present in diabetic ketoacidosis with increased morbidity.Funding proposalsUnderstanding and treating obesity’s harmful effects on rotator cuff healing
Rotator cuff injuries are extremely common and hugely debilitating. ACC data shows that rotator cuff injuries cost the New Zealand healthcare system over $113 million per annum, with approximately 1000 rotator cuff repairs performed annually.Funding proposalsImproving care and outcomes for babies at risk of brain injury
Neonatal encephalopathy (NE) is the most common cause of preventable brain injury in the newborn infant.Funding proposalsThe role of oedema and lymphatic dysfunction in critical illness
I am medically trained doctor intending to pursue a career that combines academic research with surgical practice. I have interrupted my training as a surgical registrar to embark on a PhD in order to fulfill my career goal.Funding proposalsThe role of psychological flexibility in recovery following a concussion
Concussion affects 35,000 people every year in New Zealand. It occurs following an external force to the head causing injury to the brain. Concussions can result in short and long-term psychological, physical, cognitive and social difficulties.Funding proposalsOptimising the care and outcomes for women with severe postpartum anaemia
Traditionally blood transfusions have been the standard treatment for severe postpartum anaemia. Recently, intravenous iron has become a widely used alternative.Funding proposalsNocebo Hypothesis Cognitive Behavioural Therapy (NH-CBT): an RCT
NH-CBT is a treatment protocol for functional neurological symptoms. It involves transparently sharing with the patient the hypothesis that functional neurological symptoms are the result of a nocebo effect.Funding proposalsRational extension of immunotherapy in colorectal cancer.
A new class of cancer drugs called the immune checkpoint inhibitors (ICIs) (e.g. Keytruda) are making a transformative impact on the treatment of cancers, including that of bowel cancer.Funding proposals