2305 Results
Targetting a zinc link in the treatment of Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) are characterised by impaired communication and social behaviours. ASD-associated mutations occur in the Shank family of synaptic proteins, and we have shown that these mutations weaken synapse function in the brain.Funding proposalsNovel metabolic processes to target persistent tuberculosis
Our poor understanding of the phenomenon of persistence is the greatest roadblock to improved treatment of tuberculosis (TB), leading to latent disease and severely restricting the utility of current drugs.Funding proposalsD3: Data, Decision-making & Development: using data to improve health outcomes
Routinely collected health data has been successfully used to describe “the problem” of persisting inequalities and to inform potential ‘solutions’. However, increasing attention is now being paid to data utility and relevance.Funding proposalsThe impact of racism on the future health of adults: a prospective cohort study
Racism – at an individual or structural level – is recognised as an important determinant of health.Funding proposalsTargeting IGF-1 signalling for repair of preterm brain dysmaturation
Very premature babies continue to have extremely high rates of long-term neurodevelopmental deficits.Funding proposalsRole of host exocytosis in infection of human cells by Listeria monocytogenes
Listeria monocytogenes is a potentially deadly cause of food-borne illnesses including meningitis and abortion.Funding proposalsKorero mai: taitamariki Maori development of healthy relationships
Young people’s intimate partner violence (IPV) and specifically taitamariki Māori IPV is an important issue for Aotearoa New Zealand. Māori women have higher rates (58%) of IPV than European women (34%) (Fanslow et al, 2010).Funding proposalsThe economic cost of diabetes among Pacific Islanders
This is a qualitative study looking at the health economic cost of diabetes among Pacific Islanders, living in NZ and Samoa.Funding proposalsTargeting PI3K to promote healthy ageing
New Zealanders are now living on average 10 years longer than we did in 1980. Ageing is associated with an increased incidence of chronic diseases such as type 2 diabetes, cancers, neurodegenerative and heart diseases.Funding proposalsUnderstanding the role of insulin in promoting fatty liver disease
More than 30% of New Zealanders are obese, and up to 90% of obese and 20% of non-obese suffer from non-alcoholic fatty liver disease (NAFLD). NAFLD is the accumulation of fat in the liver, and can progress to non-alcoholic steatohepatitis (NASH).Funding proposalsNaturally biased? Exploring neuropeptide signal pathway bias in pain
For many New Zealanders of all ages and ethnicities, pain is an intolerable daily burden. Pain is a major factor in diseases including arthritis, migraine and chronic lower back or hip pain.Funding proposalsGenetic modifiers of risk of familial breast and ovarian cancer
The recent development of new gene screening technologies has revolutionised genetic testing of high-risk breast and ovarian cancer patients.Funding proposalsDepression in young Samoan females: The views of mental health service providers
Evidence suggests that Pacific peoples living in New Zealand suffer from high rates of mental illness, but are less likely to access mental health services.Funding proposalsMedicine optimisation in older adults in primary care: multidisciplinary approach
A clinical pharmacist specialising in medicine optimisation in older adults, I wish to pursue a research career investigating novel models of clinical pharmacy services in community settings addressing health outcome disparities in New Zealand.Funding proposalsEnvironmental and genetic risk factors for cleft lip and palate
Oro-facial cleft (OFC) is one of the most common congenital anomalies at birth and requires long-term multidisciplinary treatment.Funding proposalsImproving outcomes after cardiothoracic surgery
Cardiovascular disease, including heart disease, is the leading cause of death in NZ accounting for one third of deaths and in addition causing a significant burden on the health system.Funding proposalsTo suction or not to suction - that is the question
This research proposal is a planned programme of research into the use, attitudes and planned avoidance of endotracheal suction (ETS) in the Intensive Care Unit.Funding proposalsPacific Islands families: cultural resiliency and vulnerability in mental health
The aims of the project are to identify the specific cultural and acculturative factors that make some Pacific people vulnerable to mental illness and others resilient to mental illness.Funding proposalsRespiratory health of Pacific youth: risk and resilience throughout childhood
This study proposes to investigate the impact of early-life and childhood events on the respiratory health of Pacific youth aged 18-19 years.Funding proposalsKnowledge translation in the management of oxygen therapy in Intensive Care
More than 20,000 New Zealanders (and 20M people globally) are admitted to intensive care units (ICU) annually.Funding proposalsRandomized controlled trial of hearing aids to improve cognition in older NZers
Untreated hearing loss speeds up age-related decline in our ability to process & understand information. Hearing aids can slow or halt this decline. Some technology used in hearing aids requires fast thinking that can be impaired with age.Funding proposalsSleep and well-being among Pacific children and adolescents
Ensuring children and adolescents receive sufficient good-quality sleep is critical for their physical and emotional health.Funding proposalsCurbing the tide of violence! Exploring a Pacific psychological faith-quotient
Violence is a serious issue across communities within Aotearoa NZ today. Commissioned reports, academic publications and media commentaries regularly highlight the exhaustive costs of violence to those involved and society at large.Funding proposalsHe Tapu te whare tangata
Maori women are more than twice as likely to be diagnosed with cervical cancer and three times more likely to die of cervical cancer than Pakeha women. The Human Papilloma Virus (HPV) is the cause of cervical cancer.Funding proposalsEffectiveness of ūloa model
Pacific peoples have been found to have a higher prevalence of mental illness than the general population and current mental health services have been unable to meet these needs.Funding proposalsTiming of initiation of renal support in acute kidney injury (STARRT-AKI)
Acute Kidney Injury (AKI) is a common problem that affects 67% of patients admitted to the intensive care unit (ICU). AKI is associated with much worse patient outcomes including increased risk of death and the requirement for long-term dialysis.Funding proposalsTaiohe and whānau entering acute mental health with alcohol and drug issues
This is a transformative qualitative study which attempts to define taiohe and whanau experiences with acute mental health issues where drugs/alcohol are implicated. Taiohe are approximately fifty percent of the Maori population.Funding proposalsCommunity support for a community mobilisation model of violence prevention
This development grant aims to mitigate the costs of consulting local stakeholders about the next phase of a research project that has been strengthening capacity for a SASA! type model of community mobilisation in Hauraki.Funding proposalsHousing, violence and ancestral land
This development grant seeks an opportunity to consult our community about their willingness to engage in the development of a research project that will identify, and test, our own solutions to the escalating violence that is occurring in our community.Funding proposalsThe molecular pathological epidemiology of NHL
The research will assess the relationship among similar and disparate risk factors for various types of non-Hodgkin lymphoma (NHL) and variations in the gene controlling mechanisms that are passed on when cells divide.Funding proposalsAre treatments for COPD increasing the risk of acute coronary syndrome?
Acute coronary syndrome (heart attacks and unstable angina) and chronic obstructive pulmonary disease (COPD) are among the commonest reasons for hospital admission and death in New Zealand.Funding proposalsCan pre-screening reduce the risk of life-threatening fluoropyrimidine toxicity?
Fluoropyrimidine drugs such as 5-FU are used to treat colorectal cancer and metastatic breast cancer. Unfortunately severe and even life-threatening side effects occur in a substantial number of patients.Funding proposals