2305 Results
Mā te mōhio ka mārama (M2M). Impact of COVID-19 on Māori:non-Māori inequities
This study will document the impact of COVID-19 pandemic management on Māori:non-Māori inequities in health at both a nation-wide and regional level.Funding proposalsNeuron-glia regulation of plasticity in health and neuroinflammatory diseases
Plasticity at synaptic junctions between nerve cells is fundamental to learning and memory. Such plasticity is generated not only by nerve cell activity, but it is also highly regulated by activity in nearby non-neural cells.Funding proposalsWhiria te tāngata: Out-of-home mobility of Māori and non-Māori over 65 (NZPATHS)
Stopping driving can result in depression, declining health, and social isolation. Transitions to driving cessation and alternative transport can be difficult for older drivers and whānau/families.Funding proposalsDevelopment of rifampicin as inhaled therapy for tuberculosis
Tuberculosis causes over ten million infections and over one million deaths each year. Treatment requires a long course of multiple antibiotics and is suboptimal: poor adherence, side effects, antibiotic resistance and treatment failure are common.Funding proposalsImproving genetic health through RNA diagnostics
The development of next-generation sequencing technologies over the past decade has revolutionised genetic testing of high-risk cancer patients in a diagnostic setting.Funding proposalsIs Exendin-4 neuroprotective after perinatal hypoxia-ischaemia?
Low oxygen and impaired blood supply to the brain (hypoxia-ischaemia, (HI)) around birth is associated with death, brain damage and disability in about 2/1000 live term births in New Zealand.Funding proposalsBringing precision to the diagnosis of complex neurodevelopmental disorders
Neurodevelopmental disorders affect 3-5% of children but frequently management options are limited by diagnostic imprecision.Funding proposalsWhat does dementia mean for Pacific communities in New Zealand?
There are no Pacific terms for dementia. The aging Pacific population will see a 2.5-fold increase in those aged 65+ by 2026.Funding proposalsHormones and mood: Imaging the impact of obesity on maternal neural circuitry
Healthy mother-infant interactions are critically important for a child’s development.Funding proposalsRegulating retail vaping to support smoking cessation
E-cigarette use in Aotearoa/New Zealand has increased rapidly in recent years, particularly among youth and Māori.Funding proposalsActivity of orexigenic AgRP neurons during pregnancy and lactation
Expecting mothers need to increase food intake to meet the energy demands of the growing fetus, and to store energy as fat in preparation for lactation.Funding proposalsImmune cells, bacteria and epithelium in Crohn's disease patients
Approximately 15 000 people in New Zealand are diagnosed with Crohn’s disease (CD), a chronic inflammatory disease that mainly affects the gut.Funding proposalsIs acute rheumatic fever primarily caused by scabies? A case-control study.
Increasing evidence suggests that acute rheumatic fever (ARF) is primarily caused by scabies infestation.Funding proposalsEvaluating a bedside high-sensitivity troponin within a rural chest pain pathway
Currently patients that present to most rural health facilities do not have access to the same highly precise and sensitive blood tests used to investigate chest pain suspected to be from a cardiac cause.Funding proposalsTargeted immune stimulants to hypersensitise lung cancer to checkpoint blockade
In Aotearoa New Zealand, 9 out of 10 lung cancer patients die within five years despite treatment, with the mortality rate for Māori being 3.5 times greater than for non-Māori.Funding proposalsRole of polarized exocyosis in infection of host cells by pathogenic E. coli
Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are important causes of diarrhoeal disease and hemolytic uremic syndrome in New Zealand and worldwide.Funding proposalsA single-cell transcriptomic approach to gastric cancer heterogeneity
Cancer cells within single tumours are not all the same. Consequently, drug therapies often fail to kill the entire cancer, leading to rapid relapse.Funding proposalsCaffeine to improve neurodevelopmental outcomes in infants born late preterm
Over 3,000 babies in New Zealand are born late preterm (4-6 weeks early) every year. Late preterm babies are at greater risk of disability when they get older than babies born at term.Funding proposalsA vaccine for Staphylococcus aureus
Staphylococcus aureus causes hospital and community acquired disease world-wide and the steady rise of antibiotic resistant strains of S. aureus is of global concern.Funding proposalsTargeting metabolic dysregulation to eradicate drug resistant M. tuberculosis
Antimicrobial resistance is a global health crisis. Drug-resistant strains of Mycobacterium tuberculosis, the causative agent of tuberculosis, are extremely difficult to treat, with long treatment regimens (9-20 months) and low cure rates (2-50%).Funding proposalsThe evaluation of treatment outcomes for methamphetamine dependence in Aotearoa
Methamphetamine (MA) is the second most commonly used illicit drug in Aotearoa New Zealand (NZ).Funding proposalsWNT signalling - a matter of degradation
In healthy animals, cellular processes precisely determine the number and type of cells. One pathway, referred to as WNT signalling, is required for embryonic development and maintaining adult stem cells.Funding proposalsDevelopment of safe, non-addictive pain medications
There is an urgent need for the development of effective pain medication that is also safe. Current pain medications targeting the mu-opioid receptor such as morphine, fentanyl and tramadol are addictive, and are ineffective when used long term.Funding proposalsExploring a twin-track approach to violence elimination for disabled women
Disabled people represent 24% of the New Zealand population, and are twice as likely to experience interpersonal violence than people without lived experience of disability. Disabled women are overrepresented within these statistics.Funding proposalsUnderstanding the impact of rurality on health outcomes and healthcare delivery
Aotearoa/New Zealand has undertaken much less research into the health status of its rural communities than have comparable countries. A barrier to this has been the absence of an agreed definition of 'rural'.Funding proposalsOvercoming antibody-drug conjugate resistance in HER2-positive breast cancer
Antibody-drug conjugates (ADCs), where potent cytotoxins are linked to antibodies for selective delivery to tumours, are approved for the treatment of HER2-positive breast cancer. However, their use is limited by drug resistance.Funding proposalsCritical evaluation of a tumour-targeted cancer therapy for clinical development
Many cancers that disproportionately affect Māori are caused by amplification, mutation or gene fusions in the Fibroblast Growth Factor Receptor (FGFR) family.Funding proposalsThe nGVS study for bilateral vestibular disorders
The inner ear, or vestibular system, is important for the maintenance of balance. Containing specialised receptors, it detects head movement in three-dimensions.Funding proposalsClimate change, heat exposure and child health
Exposure to hot temperatures, even in cooler climates, can lead to significant adverse health outcomes. An estimated 37% of recent heat-related deaths globally have been attributed to human-induced climate change.Funding proposalsA dual-safety system to promote CAR T cell activation and migration
Chimeric antigen receptor (CAR) T cell therapy involves treatment of cancer with genetically-engineered immune cells. However, successful CAR T cell therapy of solid cancers is limited by migration and activation of CAR T cells at the tumour site.Funding proposalsARISE FLUIDS Aotearoa Randomised Controlled Trial
Severe infections are a common cause of hospitalisation and outcomes for Māori are worse. These infections are treated with large volume fluids through a vein (IV fluid) and medicine to increase blood pressure (vasopressors) if fluids fail.Funding proposalsSpatial profiling of tumour tissue to improve lung cancer immunotherapy
Lung cancer has killed more New Zealanders than any other cancer, and is the most common cause of cancer death in Māori.Funding proposals