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Targeted drug delivery to the stomach

36 months
Approved budget:
Professor Parry Guilford
Dr Allan Gamble
Dr Jessica Fairhall
Health issue:
Cancer (oncology)
Proposal type:
Lay summary
Cancer drug therapy must find a balance between the inhibition of tumour growth and the unavoidable side effects of treatment. This balance usually involves compromise, leading to sub-optimal tumour inhibition and ‘tolerable’ but still debilitating toxicity to the patient. One means to avoid this compromise is tissue-specific targeting. For most tissues, this is very difficult or impractical. However, the accessibility and unique physiology of the stomach provides a unique opportunity to deliver high-dose cancer chemotherapy to this organ without dose-limiting side effects. We propose to develop a drug delivery system for the better treatment of localised stomach cancer and its precursor lesions.