Traumatic brain injury (TBI) is a high-profile public health issue. Up to 90% of all TBI are considered as mild (mTBI), many of whom still experience long-term cognitive impairments, which is often described as a storm in the brain. But we do not know why some recover quickly while others go on experiencing long-term consequences. We aim to provide a transformative solution to this problem by predicting how structural damages leads to brain’s functional changes. We will combine the key technologies in brain injury analysis namely 1) advanced magnetic resonance imaging methods; 2) a computational modelling for simulating disruptions in the whole brain connectivity; 3) a high throughput brain mechanical device for measuring brain’s electrical property change after mTBI. When combined together, this will have potential to transform the brain injury analysis by identifying pathways that cause severe cognitive impairments and the mechanisms that drive such detrimental changes.