Knee osteoarthritis (OA) is a significant health condition, resulting in disability, reduced quality of life and high societal costs. OA pain is linked to heightened sensitivity of the sensory, cognitive, emotional functioning and pain modulatory areas of the brain. Targeting treatments to self-regulate brain areas related to pain experience in people with knee OA could be a feasible way to improve clinical outcomes. Self-regulatory interventions such as Mindfulness Meditation (MM) training and Neurofeedback (NF) training are effective in improving chronic pain outcomes. However, there is no evidence investigating the effectiveness, mechanisms and cost-effectiveness of these two self-regulation training methods in people with knee osteoarthritis. A feasibility trial will address factors that could influence the design of the full trial. The feasibility trial will evaluate feasibility, safety, acceptability and experiences of the interventions and determine the variability of the outcome measures to inform the sample size of the full clinical trial.