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Role of PA28β isoform in gastric cancer cell function

Year:
2025
Duration:
3 months
Approved budget:
$7,500.00
Researchers:
Miss Isabel Gallagher
,
Dr Silke Neumann
,
Associate Professor Sharon Pattison
,
Dr Cushla McKinney
Host:
University of Otago
Health issue:
Cancer (oncology)
Proposal type:
Māori Health Summer Studentship
Lay summary
The proposed study aims to investigate the role of the new PA28β protein variant form in gastric cancer cell function. This protein binds with another to form the PA28 complex which combines with the immunoproteasome to increase its activity. This research aims to understand the biological relevance of the standard and the variant form of the PA28β protein. This project involves techniques such as cell culturing, cell counts and PCR. By undertaking this research, there is potential for better treatment options to be developed, improving the health outcomes for Māori people, who are disproportionately impacted by gastric cancer. Currently, I study medical laboratory science at Otago University, with plans to become a health professional in Aotearoa. I also have an interest in pursuing research that relates to Māori health in the future, with a focus in the pathology and cancer research fields.