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Rewiring risk: Catching pain in the act with early preventive neuromodulation

Year:
2026
Duration:
24 months
Approved budget:
$150,000.00
Researchers:
Dr Divya Adhia
,
Professor Dirk De Ridder
,
Associate Professor Ramakrishnan Mani
Host:
University of Otago
Health issue:
Neurological (CNS)
Proposal type:
Explorer Grant
Lay summary
Many people in Aotearoa New Zealand develop chronic pain that becomes long-lasting and difficult to treat, yet research suggests it may be possible to intervene before pain becomes chronic. Chronic pain places a heavy burden on individuals, families, and the health system. Most treatments begin only after pain has become entrenched, limiting their effectiveness. This project tests a new idea: using early, non-invasive brain stimulation to reduce the risk of chronic pain developing. We will target three major brain networks that process attention, self-reflection, and sensory signals, aiming to shift vulnerable brain states toward healthier patterns. This approach focuses on prevention rather than treating established pain. If successful, this research could lead to earlier and more cost-effective strategies to prevent chronic pain, reducing long-term healthcare use and improving quality of life. By exploring a high-risk, high-reward approach, it has the potential to transform how pain is understood and managed in New Zealand.