Population screening programmes begin with an invitation to participate. Ensuring people are making an informed choice to participate in screening, and reducing the opportunity for inequality to become embedded at the invitation stage, should be central to healthcare policy, but this is currently not the case; and in particular, is not the case for prenatal screening. Our study explores Māori and non-Māori women’s and healthcare practitioners’ views of informed choice regarding prenatal screening, and juxtaposes these against Māori cultural views of what information is required for Māori to make an informed prenatal screening decision. A meta-review will also be undertaken of informational prejudices associated with informed choice. Together, these research components will contribute to the collaborative design, with stakeholders, of an informed choice model for prenatal screening that will facilitate equity in prenatal screening, and potentially equity in population screening more broadly.