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The placental clock: Investigating mechanisms of stillbirth

48 months
Approved budget:
Dr Meghan Hill
Dr Kate Bartlett
Health issue:
Obstetric complications/perinatal care
Proposal type:
Explorer Grant
Lay summary
We intend to perform a large-scale biobanking project in which tissue for histology and RNA analysis is collected from women at risk for stillbirth. Samples will be collected and categorized by week of gestation, maternal ethnicity, smoking status, diabetes status and foetal sex. Histologic samples will be assessed for standard parameters and RNA expression determined for placental Corticotropin Releasing Hormone, placental progesterone and placental oestrogen.