Lay summary
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, with 10-20% of patients diagnosed with early-onset (EO) PD (under 50-years). Faults in the PINK1 gene usually only affects 4% of people with EOPD. However, we’ve found one particular faulty copy, called PINK1:L347P to cause 76% of the EOPD in Pacific patients we have tested to date.
The prevalence of PINK1 EOPD in Pacific populations is unprecedented. Yet it is only through our research that many people are finding out that they have a genetic form of PD and are connecting with other people like themselves. Our recent talanoa study has highlighted that we need to raise awareness of this disorder within Pacific and wider communities, and with health professionals. We aim to 1)raise public awareness to increase understanding, 2)determine nationwide prevalence of PINK1 EOPD, and 3)consult patients to maximise engagement in research and improve health outcomes.