Lay summary
Chronic low back pain (CLBP) is a disabling condition worldwide, associated with huge economic costs. Current available treatments, targeting low back structures that are believed to be associated with pain and disability, demonstrate at best small effect sizes, thus warranting the need for new innovative therapies. In individuals with CLBP, brain imaging studies demonstrate abnormal electrical activities in the specific cortical areas that are responsible for pain modulation, emotional and sensory components of pain experience. Moreover, these altered cortical activities are associated with pain severity and chronicity. Targeting those key brain regions may produce clinical benefits. The proposed research will evaluate the feasibility and safety of a novel non-invasive neuromodulation paradigm, a high definition transcranial infraslow pink noise stimulation (HD-tIPNS) technique, targeting multiple brain regions simultaneously, for modulating abnormal electrical activity in people with CLBP.