Efforts are underway within indigenous communities in New Zealand, Australia, Canada and the USA to remedy the health care issues of indigenous children who misuse substances. The topic of indigenous-led community based health solutions has received little attention. The aim of the research is to develop new knowledge and capacity to remedy substance misuse in indigenous children under 13 years through a comparative study of indigenous-health-practitioner led community based solutions from New Zealand, Australia, Canada and the USA that focus on whānau rangatiratanga/family self-determination. The research is an indigenous qualitative study using a narrative based community case study approach. An inductive qualitative data analysis process will be applied. The outcomes will include collaborative web-based materials shared through an open source information platform to support practitioners, families, communities and stakeholders to develop health solutions unique to each child.