Lay summary
Pacific peoples are at higher risk of severe clinical outcomes from viral infections including RSV, influenza and SARS-CoV-2 (cause of COVID-19). We need additional antivirals to protect Pacific communities, especially those with co-morbidities, which can contraindicate currently approved antivirals. Pacific peoples utilise traditional medicines to treat many illnesses. Several exhibit potent anti-inflammatory and antimicrobial properties, however, few studies have directly examined the antiviral effects against current viral threats. Engaging with and guided by traditional healers, we will examine Samoan traditional medicines for antiviral activities against several pathogenic viruses. We will use virological assays, then isolate the active components using chromatographic and analytical methods to probe the underlying antiviral mechanisms of the medicinal homogenate and active chemical constituents. Through the combined expertise and complementary skillsets of Pacific traditional medicine knowledge holders, chemists and virologists, this research will enhance traditional knowledge and identify effective traditional antivirals for improved protection of our communities.