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Glycotoxicity in the diabetic heart - novel treatment targets

Year:
2019
Duration:
48 months
Approved budget:
$1,148,222.25
Researchers:
Dr Kim Mellor
Health issue:
Diabetes
Proposal type:
Project
Lay summary
Diabetes is an epidemic disease, and is associated with specific damage to the heart. The nature of this injury is poorly understood and there is no specific therapy. In this project we investigate the role of abnormal glucose handling in promoting toxic accumulation of glycogen deposits in the heart and in damaging the proteins which are key in regulating effective contraction and heart pump action. The aim is to develop a strategy to prevent or reduce cardiac glucose damage in diabetes.