Lay summary
Dr Angus Lindsay is developing an internationally recognised research program to understand the molecular mechanisms regulating neuronal and skeletal muscle dysfunction in Duchenne muscular dystrophy (DMD). Dr Lindsay has received back-to-back competitive research fellowships, trained with distinguished scholars in the USA and Australia, presented at multiple international conferences, acquired independent funding, published 51 research articles, and has been appointed as an international consultant for muscular dystrophy therapies and coordinator of the Australian Society for Medical Research Grant Scheme. Dr Lindsay’s research aims to enable generation of an acute hypertensive response in the mdx mouse model of DMD to prevent stress-induced death by hypotension. He will achieve this using gene therapy and oestrogen-based strategies that will directly inform clinical practice to prevent stress-induced hypotension in patients with DMD. Outcomes to emerge from these studies offer a real prospect of fine-tuning treatment strategies for the hundreds of New Zealanders living with DMD.