Lay summary
Screening mammography is proven to reduce breast cancer mortality and morbidity in Aotearoa. However, for some cohorts, it is not as accessible (wāhine Māori, women in high deprivation quintiles) or effective (women with dense breasts). Mammography is resource-intensive, making age extension in line with new evidence (40-44) extremely challenging. These limitations are common worldwide; as a result, the role of new blood tests as a mammography adjunct or alternative in targeted cohorts is under investigation internationally. We will work with primary health organisation ProCare to develop a proposed clinical pathway for an in-market Canadian breast cancer screening blood test for Māori and Pacific women aged 40-44 (who are at higher risk of breast cancer but not eligible for mammography screening). A sample cohort will be tested in accordance with this pathway, enabling improvement to the pathway and optimal cohort identification for a larger research investigation.