Lay summary
Women at high-risk of breast and ovarian cancer need new and effective prevention strategies. Traditional options for cancer prevention include risk-reducing surgery, however this strategy is unwanted by many women due to a variety of reasons, such as fertility and menopause concerns. Providing doctors with a non-invasive and easily accessible preventative therapy for women at high risk of developing breast and ovarian cancer would have numerous benefits for the health system (e.g. reduced inequity in health outcomes), and for the patients and their whānau. Through a recent novel discovery in my laboratory, and collaboration with the world leading CIMBA Consortium, I am uniquely positioned to investigate potential novel preventative therapies for women at high-risk of breast and ovarian cancer. This innovative and potentially transformative research programme will provide a step towards reducing cancer diagnoses through the development of personalised preventative treatment(s).