Lay summary
Oligonucleotide therapies, made from molecules similar to RNA and DNA, are one of the most promising therapies that are already finding limited use against rare diseases, and will be used in the near future to treat cancer. This project will screen the vast number of potential modifications to the structure of oligonucleotides that are possible, conducting a literature review to rank them based on their likelihood to be a feasible way of improving current candidates being locally screened for use against colorectal cancer. The synthetic techniques used to generate the highest ranking candidates will be learned and tested in the lab, to provide a proof of principle test cancer therapy molecule.