Lay summary
Proteins are essential for life. There are a multitude of different proteins that play many different roles within cells and living organisms. Each protein must be found in the right type of cell, in the right amount, and at the right time otherwise disease can occur. This project focuses on four proteins involved in human cancer called TRIB2, STK40, RNF125 and FZD. Further research on these proteins and their roles is needed. However, studying these proteins in the lab requires them to be made artificially and difficulties are encountered in their production. This project involves using artificial intelligence to design new versions of these proteins. As a result, they can be produced and studied more easily. This is important since there is the potential for new cancer therapies to be developed that target these proteins, which would ultimately improve patient outcomes.