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Pharmacological determinants of oxaliplatin neurotoxicity in cancer patients

47 months
Approved budget:
Dr Hye-won Han
Health issue:
Cancer (oncology)
Proposal type:
Clinical Research Training Fellowship
Lay summary
I am a medical graduate and practising physician who has completed basic physician training and soon will have completed advanced training in medical oncology. Before taking up a senior clinical role in a NZ hospital as a Consultant Medical Oncologist, I seek to complete a period of full-time clinical research training towards a PhD, with the support of an HRC Clinical Research Training Fellowship. Oxaliplatin-based chemotherapy has improved survival and become a standard of care for colorectal cancer patients in both adjuvant and palliative settings, but its toxicity is a limitation. The overall goal of my project is to gain new understanding of actionable determinants of oxaliplatin-induced neurotoxicity in cancer patients, with the aim of improving their clinical outcomes from therapy. Towards this goal, I will undertake prospective clinical studies of calcium and magnesium infusions for limiting oxaliplatin neurotoxicity, and of its potential association with baseline variables in colorectal cancer patients undergoing chemotherapy.